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3ifi

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{{Seed}}
 
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[[Image:3ifi.png|left|200px]]
 
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==2'-SeMe-dG modified octamer DNA==
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The line below this paragraph, containing "STRUCTURE_3ifi", creates the "Structure Box" on the page.
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<StructureSection load='3ifi' size='340' side='right'caption='[[3ifi]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ifi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IFI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XUG:2-SE-METHYL-2-SELENOGUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>XUG</scene></td></tr>
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{{STRUCTURE_3ifi| PDB=3ifi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ifi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifi OCA], [https://pdbe.org/3ifi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ifi RCSB], [https://www.ebi.ac.uk/pdbsum/3ifi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifi ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Selenium modification of nucleic acids is of great importance in X-ray crystal structure determination and functional study of nucleic acids. Herein, we describe a convenient synthesis of a new building block, the 2'-SeMe-modified guanosine (G(Se)) phosphoramidite, and report the first incorporation of the 2'-Se-G moiety into DNA. The X-ray crystal structure of the 2'-Se-modified octamer DNA (5'-GTG(Se)TACAC-3') was determined at a resolution of 1.20 A. We also found that the 2'-Se modification points to the minor groove and that the modified and native structures are virtually identical. Furthermore, we observed that the 2'-Se-G modification can significantly facilitate the crystal growth with respect to the corresponding native DNA.
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===2'-SeMe-dG modified octamer DNA===
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Synthesis and crystal structure of 2'-se-modified guanosine containing DNA.,Salon J, Sheng J, Gan J, Huang Z J Org Chem. 2010 Feb 5;75(3):637-41. PMID:20047333<ref>PMID:20047333</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20047333}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3ifi" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20047333 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20047333}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3IFI is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFI OCA].
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[[Category: Gan J]]
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[[Category: Huang Z]]
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==Reference==
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[[Category: Salon J]]
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<ref group="xtra">PMID:20047333</ref><references group="xtra"/>
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[[Category: Sheng J]]
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[[Category: Gan, J.]]
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[[Category: Huang, Z.]]
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[[Category: Salon, J.]]
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[[Category: Sheng, J.]]
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[[Category: Dna]]
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[[Category: Guanosine]]
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[[Category: Nucleic acid]]
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[[Category: Selenium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:58:13 2010''
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Current revision

2'-SeMe-dG modified octamer DNA

PDB ID 3ifi

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