2wbb

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{{Seed}}
 
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[[Image:2wbb.png|left|200px]]
 
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==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR==
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The line below this paragraph, containing "STRUCTURE_2wbb", creates the "Structure Box" on the page.
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<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr>
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{{STRUCTURE_2wbb| PDB=2wbb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [https://pdbe.org/2wbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [https://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wbb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sulfonylureido thiazoles were identified from a HTS campaign and optimized through a combination of structure-activity studies, X-ray crystallography and molecular modeling to yield potent inhibitors of fructose-1,6-bisphosphatase. Compound 12 showed favorable ADME properties, for example, F=70%, and a robust 32% glucose reduction in the acute db/db mouse model for Type-2 diabetes.
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===FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR===
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Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.,Kitas E, Mohr P, Kuhn B, Hebeisen P, Wessel HP, Haap W, Ruf A, Benz J, Joseph C, Huber W, Sanchez RA, Paehler A, Benardeau A, Gubler M, Schott B, Tozzo E Bioorg Med Chem Lett. 2010 Jan 15;20(2):594-9. Epub 2009 Nov 22. PMID:19969452<ref>PMID:19969452</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2wbb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19969452}}, adds the Publication Abstract to the page
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*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19969452 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19969452}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2WBB is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA].
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==Reference==
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<ref group="xtra">PMID:19969452</ref><references group="xtra"/>
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[[Category: Fructose-bisphosphatase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Benz, J.]]
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[[Category: Large Structures]]
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[[Category: Bernadeau, A.]]
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[[Category: Alvarez Sanchez R]]
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[[Category: Fol, B.]]
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[[Category: Benz J]]
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[[Category: Gubler, M.]]
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[[Category: Bernadeau A]]
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[[Category: Haap, W.]]
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[[Category: Fol B]]
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[[Category: Hebeisen, P.]]
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[[Category: Gubler M]]
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[[Category: Huber, W.]]
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[[Category: Haap W]]
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[[Category: Joseph, C.]]
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[[Category: Hebeisen P]]
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[[Category: Kitas, E.]]
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[[Category: Huber W]]
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[[Category: Kuhn, B.]]
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[[Category: Joseph C]]
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[[Category: Mohr, P.]]
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[[Category: Kitas E]]
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[[Category: Paehler, A.]]
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[[Category: Kuhn B]]
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[[Category: Ruf, A.]]
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[[Category: Mohr P]]
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[[Category: Sanchez, R Alvarez.]]
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[[Category: Paehler A]]
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[[Category: Schott, B.]]
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[[Category: Ruf A]]
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[[Category: Tetaz, T.]]
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[[Category: Schott B]]
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[[Category: Tozzo, E.]]
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[[Category: Tetaz T]]
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[[Category: Wessel, H P.]]
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[[Category: Tozzo E]]
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[[Category: Allosteric enzyme]]
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[[Category: Wessel HP]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Gluconeogenesis]]
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[[Category: Hydrolase]]
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[[Category: Phosphoric monoester]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:00:34 2010''
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Current revision

FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR

PDB ID 2wbb

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