3l32

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{{Seed}}
 
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[[Image:3l32.jpg|left|200px]]
 
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==Structure of the dimerisation domain of the rabies virus phosphoprotein==
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The line below this paragraph, containing "STRUCTURE_3l32", creates the "Structure Box" on the page.
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<StructureSection load='3l32' size='340' side='right'caption='[[3l32]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l32]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_virus_China/MRV Rabies virus China/MRV]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L32 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l32 OCA], [https://pdbe.org/3l32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l32 RCSB], [https://www.ebi.ac.uk/pdbsum/3l32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l32 ProSAT]</span></td></tr>
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{{STRUCTURE_3l32| PDB=3l32 | SCENE= }}
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</table>
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== Function ==
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===Structure of the dimerisation domain of the rabies virus phosphoprotein===
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[https://www.uniprot.org/uniprot/PHOSP_RABVR PHOSP_RABVR] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20089657 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/3l32_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_20089657}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l32 ConSurf].
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3L32 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L32 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:20089657</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Rabies virus]]
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[[Category: Rabies virus China/MRV]]
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[[Category: Crepin, T.]]
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[[Category: Crepin T]]
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[[Category: Ivanov, I.]]
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[[Category: Ivanov I]]
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[[Category: Jamin, M.]]
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[[Category: Jamin M]]
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[[Category: Ruigrok, R W.H.]]
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[[Category: Ruigrok RWH]]
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[[Category: Antiparallel alpha-helice]]
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[[Category: Dimerisation domain]]
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[[Category: Phosphoprotein]]
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[[Category: Rabies virus]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:22:09 2010''
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Current revision

Structure of the dimerisation domain of the rabies virus phosphoprotein

PDB ID 3l32

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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