3kj0

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{{Seed}}
 
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[[Image:3kj0.jpg|left|200px]]
 
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<!--
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==Mcl-1 in complex with Bim BH3 mutant I2dY==
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The line below this paragraph, containing "STRUCTURE_3kj0", creates the "Structure Box" on the page.
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<StructureSection load='3kj0' size='340' side='right'caption='[[3kj0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KJ0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_3kj0| PDB=3kj0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kj0 OCA], [https://pdbe.org/3kj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3kj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kj0 ProSAT]</span></td></tr>
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</table>
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===Mcl-1 in complex with Bim BH3 mutant I2dY===
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== Function ==
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[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_20066663}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 20066663 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/3kj0_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20066663}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3KJ0 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJ0 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kj0 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:20066663</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fire, E.]]
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[[Category: Large Structures]]
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[[Category: Grant, R A.]]
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[[Category: Fire E]]
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[[Category: Keating, A E.]]
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[[Category: Grant RA]]
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[[Category: Alternative splicing]]
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[[Category: Keating AE]]
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[[Category: Apoptosis]]
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[[Category: Bcl-2]]
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[[Category: Bh3]]
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[[Category: Cytoplasm]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Isopeptide bond]]
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[[Category: Membrane]]
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[[Category: Mitochondrion]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein-peptide complex]]
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[[Category: Transmembrane]]
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[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:26:57 2010''
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Current revision

Mcl-1 in complex with Bim BH3 mutant I2dY

PDB ID 3kj0

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