3ld9

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{{Seed}}
 
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[[Image:3ld9.jpg|left|200px]]
 
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==Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution==
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The line below this paragraph, containing "STRUCTURE_3ld9", creates the "Structure Box" on the page.
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<StructureSection load='3ld9' size='340' side='right'caption='[[3ld9]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ld9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ehrlichia_chaffeensis_str._Arkansas Ehrlichia chaffeensis str. Arkansas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LD9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ld9| PDB=3ld9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ld9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld9 OCA], [https://pdbe.org/3ld9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ld9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ld9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ld9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_EHRCR KTHY_EHRCR] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ld9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ld9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The enzyme thymidylate kinase phosphorylates the substrate thymidine 5'-phosphate (dTMP) to form thymidine 5'-diphosphate (dTDP), which is further phosphorylated to dTTP for incorporation into DNA. Ehrlichia chaffeensis is the etiologic agent of human monocytotropic erlichiosis (HME), a potentially life-threatening tick-borne infection. HME is endemic in the United States from the southern states up to the eastern seaboard. HME is transmitted to humans via the lone star tick Amblyomma americanum. Here, the 2.15 A resolution crystal structure of thymidylate kinase from E. chaffeensis in the apo form is presented.
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===Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution===
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Structure of thymidylate kinase from Ehrlichia chaffeensis.,Leibly DJ, Abendroth J, Bryan CM, Sankaran B, Kelley A, Barrett LK, Stewart L, Van Voorhis WC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1090-4. Epub 2011 Aug 16. PMID:21904055<ref>PMID:21904055</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ld9" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3LD9 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Ehrlichia_chaffeensis Ehrlichia chaffeensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD9 OCA].
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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[[Category: Ehrlichia chaffeensis]]
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== References ==
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[[Category: DTMP kinase]]
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<references/>
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[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
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__TOC__
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[[Category: Als collaborative crystallography]]
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</StructureSection>
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[[Category: Atp-binding]]
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[[Category: Ehrlichia chaffeensis str. Arkansas]]
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[[Category: Ehrlichia chaffeensis]]
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[[Category: Large Structures]]
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[[Category: Emerald biostructure]]
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[[Category: Kinase]]
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[[Category: Niaid]]
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[[Category: Nih]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: Nucleotide-binding]]
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[[Category: Sbri]]
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[[Category: Seattle structural genomics center for infectious disease]]
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[[Category: Ssgcid]]
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[[Category: Structural genomic]]
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[[Category: Thymidylate kinase]]
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[[Category: Transferase]]
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[[Category: Uw]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:53:43 2010''
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Current revision

Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution

PDB ID 3ld9

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