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2fkp

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(New page: 200px<br /><applet load="2fkp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fkp, resolution 2.00&Aring;" /> '''The mutant G127C-T31...)
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[[Image:2fkp.gif|left|200px]]<br /><applet load="2fkp" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2fkp, resolution 2.00&Aring;" />
 
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'''The mutant G127C-T313C of Deinococcus Radiodurans N-acylamino acid racemase'''<br />
 
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==About this Structure==
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==The mutant G127C-T313C of Deinococcus Radiodurans N-acylamino acid racemase==
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2FKP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. This structure superseeds the now removed PDB entry 2BAH. Active as [http://en.wikipedia.org/wiki/Amino-acid_racemase Amino-acid racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.10 5.1.1.10] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FKP OCA].
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<StructureSection load='2fkp' size='340' side='right'caption='[[2fkp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: Amino-acid racemase]]
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fkp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bah 2bah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FKP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fkp OCA], [https://pdbe.org/2fkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fkp RCSB], [https://www.ebi.ac.uk/pdbsum/2fkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fkp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NSAR_DEIRA NSAR_DEIRA] Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine and N-succinyl-D/L-phenylalanine (PubMed:24872444, PubMed:25875730). Can catalyze the racemization of a broad range of N-acylamino acids, including N-acetyl-D/L-methionine, N-acetyl-D/L-phenylalanine, N-acetyl-L-glutamine, N-acetyl-L-tryptophan, N-acetyl-L-leucine, N-formyl-D-methionine, N-formyl-D-norleucine, N-carbamoyl-D-methionine and N-carbamoyl-D-norleucine (PubMed:15313614, PubMed:16650857, PubMed:25875730). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:24872444). However, NSAR activity is probably the protein's biological function, because menaquinone biosynthesis genes are missing in this species (Probable).<ref>PMID:15313614</ref> <ref>PMID:16650857</ref> <ref>PMID:24872444</ref> <ref>PMID:25875730</ref> <ref>PMID:16740275</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/2fkp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fkp ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chiu, W.C.]]
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[[Category: Chiu WC]]
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[[Category: Wang, W.C.]]
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[[Category: Wang WC]]
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[[Category: deinococcus radiodurans]]
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[[Category: n-acylamino acid racemase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 08:54:00 2007''
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Current revision

The mutant G127C-T313C of Deinococcus Radiodurans N-acylamino acid racemase

PDB ID 2fkp

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