3kd7

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{{Seed}}
 
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[[Image:3kd7.png|left|200px]]
 
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==Designed TPR module (CTPR390) in complex with its peptide-ligand (Hsp90 peptide)==
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The line below this paragraph, containing "STRUCTURE_3kd7", creates the "Structure Box" on the page.
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<StructureSection load='3kd7' size='340' side='right'caption='[[3kd7]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kd7]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KD7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_3kd7| PDB=3kd7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kd7 OCA], [https://pdbe.org/3kd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3kd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kd7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9H2A1_HUMAN Q9H2A1_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/3kd7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kd7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tetratricopeptide repeats (TPRs) are protein domains that mediate key protein-protein interactions in cells. Several TPR domains bind the C-termini of the chaperones heat shock protein (Hsp)90 and/or Hsp70, and exchange of such binding partners is key for the heat shock response. We have previously described the design of a TPR protein that binds tightly and specifically to the C-terminus of Hsp90, and in doing so, is able to inhibit chaperone function in vivo. Here we present the X-ray crystal structure of the designed TPR domain (CTPR390) in complex with its peptide ligand--the C-terminal residues of Hsp90 (peptide MEEVD). This structure reveals two interesting aspects of the TPR modules. First, a new packing arrangement of 3-TPR modules is observed. The TPR units stack against each other in an unusual fashion to form infinite superhelices in the crystal. Second, the structure provides insights into the molecular basis of TPR-ligand recognition.
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===Designed TPR module (CTPR390) in complex with its peptide-ligand (Hsp90 peptide)===
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Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand.,Cortajarena AL, Wang J, Regan L FEBS J. 2010 Feb;277(4):1058-66. Epub 2010 Jan 18. PMID:20089039<ref>PMID:20089039</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3kd7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20089039 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20089039}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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3KD7 is a 10 chains structure with sequences from [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD7 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:20089039</ref><references group="xtra"/>
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[[Category: Unidentified]]
[[Category: Unidentified]]
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[[Category: Cortajarena, A L.]]
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[[Category: Cortajarena AL]]
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[[Category: Regan, L.]]
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[[Category: Regan L]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: De novo protein]]
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[[Category: Designed protein]]
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[[Category: Hsp90 binding]]
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[[Category: Repeat protein]]
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[[Category: Superhelical structure]]
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[[Category: Tpr-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 10:02:15 2010''
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Current revision

Designed TPR module (CTPR390) in complex with its peptide-ligand (Hsp90 peptide)

PDB ID 3kd7

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