3haf

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{{Seed}}
 
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[[Image:3haf.png|left|200px]]
 
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==Human prion protein variant V129 domain swapped dimer==
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The line below this paragraph, containing "STRUCTURE_3haf", creates the "Structure Box" on the page.
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<StructureSection load='3haf' size='340' side='right'caption='[[3haf]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3haf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HAF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_3haf| PDB=3haf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3haf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3haf OCA], [https://pdbe.org/3haf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3haf RCSB], [https://www.ebi.ac.uk/pdbsum/3haf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3haf ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/3haf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3haf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A conformational transition of normal cellular prion protein (PrP(C)) to its pathogenic form (PrP(Sc)) is believed to be a central event in the transmission of the devastating neurological diseases known as spongiform encephalopathies. The common methionine/valine polymorphism at residue 129 in the PrP influences disease susceptibility and phenotype. We report here seven crystal structures of human PrP variants: three of wild-type (WT) PrP containing V129, and four of the familial variants D178N and F198S, containing either M129 or V129. Comparison of these structures with each other and with previously published WT PrP structures containing M129 revealed that only WT PrPs were found to crystallize as domain-swapped dimers or closed monomers; the four mutant PrPs crystallized as non-swapped dimers. Three of the four mutant PrPs aligned to form intermolecular beta-sheets. Several regions of structural variability were identified, and analysis of their conformations provides an explanation for the structural features, which can influence the formation and conformation of intermolecular beta-sheets involving the M/V129 polymorphic residue.
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===Human prion protein variant V129 domain swapped dimer===
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Conformational diversity in prion protein variants influences intermolecular beta-sheet formation.,Lee S, Antony L, Hartmann R, Knaus KJ, Surewicz K, Surewicz WK, Yee VC EMBO J. 2010 Jan 6;29(1):251-62. Epub 2009 Nov 19. PMID:19927125<ref>PMID:19927125</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3haf" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19927125}}, adds the Publication Abstract to the page
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*[[Prion|Prion]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19927125 is the PubMed ID number.
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_19927125}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3HAF is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAF OCA].
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==Reference==
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<ref group="xtra">PMID:19927125</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Antony, L.]]
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[[Category: Large Structures]]
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[[Category: Hartmann, R.]]
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[[Category: Antony L]]
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[[Category: Knaus, K J.]]
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[[Category: Hartmann R]]
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[[Category: Lee, S.]]
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[[Category: Knaus KJ]]
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[[Category: Surewicz, K.]]
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[[Category: Lee S]]
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[[Category: Surewicz, W K.]]
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[[Category: Surewicz K]]
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[[Category: Yee, V C.]]
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[[Category: Surewicz WK]]
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[[Category: Cell membrane]]
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[[Category: Yee VC]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Golgi apparatus]]
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[[Category: Gpi-anchor]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Polymorphism]]
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[[Category: Prion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 13:23:57 2010''
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Current revision

Human prion protein variant V129 domain swapped dimer

PDB ID 3haf

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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