2wq7

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{{Seed}}
 
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[[Image:2wq7.png|left|200px]]
 
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==Structure of the 6-4 photolyase of D. melanogaster in complex with the non-natural N4-methyl T(6-4)C lesion==
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The line below this paragraph, containing "STRUCTURE_2wq7", creates the "Structure Box" on the page.
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<StructureSection load='2wq7' size='340' side='right'caption='[[2wq7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wq7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQ7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=TDY:5-(METHYLAMINO)THYMIDINE+5-(DIHYDROGEN+PHOSPHATE)'>TDY</scene>, <scene name='pdbligand=Z:1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)PYRIMIDIN-2(1H)-ONE'>Z</scene></td></tr>
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{{STRUCTURE_2wq7| PDB=2wq7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wq7 OCA], [https://pdbe.org/2wq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wq7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wq7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8SXK5_DROME Q8SXK5_DROME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wq7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wq7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Repair of the Dewar valence isomers by (6-4) photolyases proceeds via an enzyme catalyzed ring-opening reaction of the Dewar lesion to the (6-4) photoproduct.
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===STRUCTURE OF THE 6-4 PHOTOLYASE OF D. MELANOGASTER IN COMPLEX WITH THE NON-NATURAL N4-METHYL T(6-4)C LESION===
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DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions.,Glas AF, Kaya E, Schneider S, Heil K, Fazio D, Maul MJ, Carell T J Am Chem Soc. 2010 Feb 18. PMID:20166732<ref>PMID:20166732</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2wq7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20166732 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20166732}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2WQ7 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ7 OCA].
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==Reference==
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<ref group="xtra">PMID:20166732</ref><references group="xtra"/>
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[[Category: Deoxyribodipyrimidine photo-lyase]]
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Carell, T.]]
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[[Category: Large Structures]]
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[[Category: Glas, A F.]]
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[[Category: Carell T]]
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[[Category: Kaya, E.]]
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[[Category: Glas AF]]
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[[Category: Maul, M J.]]
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[[Category: Kaya E]]
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[[Category: Schneider, S.]]
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[[Category: Maul MJ]]
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[[Category: Dna lesion]]
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[[Category: Schneider S]]
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[[Category: Dna repair]]
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[[Category: Lyase]]
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[[Category: Lyase-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 14:02:25 2010''
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Current revision

Structure of the 6-4 photolyase of D. melanogaster in complex with the non-natural N4-methyl T(6-4)C lesion

PDB ID 2wq7

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