2kt0

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{{Seed}}
 
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[[Image:2kt0.png|left|200px]]
 
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==Solution structure of human stem cell transcription factor Nanog homeodomain fragment==
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The line below this paragraph, containing "STRUCTURE_2kt0", creates the "Structure Box" on the page.
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<StructureSection load='2kt0' size='340' side='right'caption='[[2kt0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KT0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt0 OCA], [https://pdbe.org/2kt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt0 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt0 ProSAT]</span></td></tr>
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{{STRUCTURE_2kt0| PDB=2kt0 | SCENE= }}
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</table>
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== Function ==
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===Solution structure of human stem cell transcription factor Nanog homeodomain fragment===
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[https://www.uniprot.org/uniprot/NANOG_HUMAN NANOG_HUMAN] Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.<ref>PMID:15983365</ref> <ref>PMID:16000880</ref> <ref>PMID:16391521</ref> <ref>PMID:25825768</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2KT0 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT0 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/2kt0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kt0 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Large Structures]]
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[[Category: Markley, J L.]]
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[[Category: Markley JL]]
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[[Category: Sahu, S C.]]
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[[Category: Sahu SC]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
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[[Category: Dna-binding]]
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[[Category: Homeobox]]
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[[Category: Homeodomain]]
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[[Category: Nanog]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Stem cell]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 14:20:02 2010''
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Current revision

Solution structure of human stem cell transcription factor Nanog homeodomain fragment

PDB ID 2kt0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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