3k8q

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{{Seed}}
 
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[[Image:3k8q.jpg|left|200px]]
 
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==Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H==
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The line below this paragraph, containing "STRUCTURE_3k8q", creates the "Structure Box" on the page.
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<StructureSection load='3k8q' size='340' side='right'caption='[[3k8q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3k8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K8Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22A:7-({[2-HYDROXY-1-(HYDROXYMETHYL)ETHYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE'>22A</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3k8q| PDB=3k8q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8q OCA], [https://pdbe.org/3k8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k8q RCSB], [https://www.ebi.ac.uk/pdbsum/3k8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k8q ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/3k8q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k8q ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H===
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==See Also==
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*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3K8Q is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8Q OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Purine-nucleoside phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Ho, M.]]
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[[Category: Ho M]]
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[[Category: Scharmm, V L.]]
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[[Category: Scharmm VL]]
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[[Category: Acetylation]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Glycosyltransferase]]
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[[Category: Hpnp]]
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[[Category: Immucillin h]]
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[[Category: Pnp]]
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[[Category: Polymorphism]]
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[[Category: Serme-immh]]
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[[Category: Transferase]]
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[[Category: Transition state analog inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 17:12:56 2010''
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Current revision

Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H

PDB ID 3k8q

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