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1auz

From Proteopedia

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[[Image:1auz.gif|left|200px]]<br /><applet load="1auz" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1auz" />
 
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'''SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS, NMR, 24 STRUCTURES'''<br />
 
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==Overview==
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==SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS, NMR, 24 STRUCTURES==
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The establishment of differential gene expression in sporulating Bacillus, subtilis involves four protein components, one of which, SpoIIAA, undergoes phosphorylation and dephosphorylation. We have used NMR, spectroscopy to determine the solution structure of the nonphosphorylated, form of SpoIIAA. The structure shows a fold consisting of a four-stranded, beta-sheet and four alpha-helices. Knowledge of the structure helps to, account for the phenotype of several strains of B. subtilis that carry, known spoIIAA mutations and should facilitate investigations of the, conformational consequences of phosphorylation.
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<StructureSection load='1auz' size='340' side='right'caption='[[1auz]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1auz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AUZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1auz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1auz OCA], [https://pdbe.org/1auz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1auz RCSB], [https://www.ebi.ac.uk/pdbsum/1auz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1auz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SP2AA_BACSU SP2AA_BACSU] In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.<ref>PMID:8358793</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/1auz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1auz ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1AUZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Known structural/functional Site: <scene name='pdbsite=P:Phosphorylation Site In Spoiiaa Is SER 58'>P</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AUZ OCA].
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*[[Anti-sigma factor antagonist 3D structures|Anti-sigma factor antagonist 3D structures]]
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== References ==
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==Reference==
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<references/>
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Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis., Kovacs H, Comfort D, Lord M, Campbell ID, Yudkin MD, Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5067-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9560229 9560229]
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Campbell, I.D.]]
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[[Category: Campbell ID]]
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[[Category: Comfort, D.]]
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[[Category: Comfort D]]
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[[Category: Kovacs, H.]]
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[[Category: Kovacs H]]
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[[Category: Lord, M.]]
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[[Category: Lord M]]
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[[Category: Yudkin, M.D.]]
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[[Category: Yudkin MD]]
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[[Category: anti-anti sigma factor]]
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[[Category: kinase substrate]]
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[[Category: novel alpha/beta fold]]
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[[Category: transcription regulator]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:21:49 2007''
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Current revision

SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS, NMR, 24 STRUCTURES

PDB ID 1auz

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