3a01

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{{Seed}}
 
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[[Image:3a01.jpg|left|200px]]
 
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==Crystal structure of Aristaless and Clawless homeodomains bound to DNA==
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The line below this paragraph, containing "STRUCTURE_3a01", creates the "Structure Box" on the page.
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<StructureSection load='3a01' size='340' side='right'caption='[[3a01]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a01]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A01 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a01 OCA], [https://pdbe.org/3a01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a01 RCSB], [https://www.ebi.ac.uk/pdbsum/3a01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a01 ProSAT]</span></td></tr>
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{{STRUCTURE_3a01| PDB=3a01 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9VD99_DROME Q9VD99_DROME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/3a01_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a01 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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To achieve accurate gene regulation, some homeodomain proteins bind cooperatively to DNA to increase those site specificities. We report a ternary complex structure containing two homeodomain proteins, aristaless (Al) and clawless (Cll), bound to DNA. Our results show that the extended conserved sequences of the Cll homeodomain are indispensable to cooperative DNA binding. In the Al-Cll-DNA complex structure, the residues in the extended regions are used not only for the intermolecular contacts between the two homeodomain proteins but also for the sequence-recognition mechanism of DNA by direct interactions. The residues in the extended N-terminal arm lie within the minor groove of DNA to form direct interactions with bases, whereas the extended conserved region of the C-terminus of the homeodomain interacts with Al to stabilize and localize the third alpha helix of the Cll homeodomain. This structure suggests a novel mode for the cooperativity of homeodomain proteins.
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===Crystal structure of Aristaless and Clawless homeodomains bound to DNA===
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Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.,Miyazono K, Zhi Y, Takamura Y, Nagata K, Saigo K, Kojima T, Tanokura M EMBO J. 2010 May 5;29(9):1613-23. Epub 2010 Apr 13. PMID:20389279<ref>PMID:20389279</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3A01 is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A01 OCA].
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<div class="pdbe-citations 3a01" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Kojima, T.]]
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[[Category: Large Structures]]
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[[Category: Miyazono, K.]]
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[[Category: Kojima T]]
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[[Category: Nagata, K.]]
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[[Category: Miyazono K]]
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[[Category: Saigo, K.]]
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[[Category: Nagata K]]
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[[Category: Tanokura, M.]]
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[[Category: Saigo K]]
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[[Category: Developmental protein]]
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[[Category: Tanokura M]]
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[[Category: Dna-binding]]
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[[Category: Gene regulation-dna complex]]
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[[Category: Homeobox]]
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[[Category: Homeodomain]]
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[[Category: Nucleus]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 14:21:57 2010''
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Current revision

Crystal structure of Aristaless and Clawless homeodomains bound to DNA

PDB ID 3a01

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