1zxt

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{{Seed}}
 
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[[Image:1zxt.png|left|200px]]
 
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==Crystal Structure of A Viral Chemokine==
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The line below this paragraph, containing "STRUCTURE_1zxt", creates the "Structure Box" on the page.
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<StructureSection load='1zxt' size='340' side='right'caption='[[1zxt]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxt OCA], [https://pdbe.org/1zxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxt RCSB], [https://www.ebi.ac.uk/pdbsum/1zxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxt ProSAT]</span></td></tr>
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{{STRUCTURE_1zxt| PDB=1zxt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q76RJ0_HHV8 Q76RJ0_HHV8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zxt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zxt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Viral macrophage inflammatory protein I (vMIP-I) is a chemokine encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous ligand is CCL1. The crystal structure of vMIP-I was determined at 1.7A for comparison with other chemokines, especially those that bind CCR8, such as vMIP-II from KSHV, a CCR8 antagonist and the closest homolog (40% identical). vMIP-I has a typical chemokine fold consisting of an extended N-terminal loop, followed by a three-stranded antiparallel beta-sheet and a C-terminal alpha-helix. The four molecules in the asymmetric unit comprise two MIP-1beta-like dimers. Electrostatic surface representations of CCR8-binding chemokines reveal only minor areas of correlating surface potential, which must be reconciled with promiscuity in receptor and glycosaminoglycan (GAG) binding. In addition, the biological relevance of chemokine oligomerization is examined by comparing the oligomeric states of all chemokine structures deposited to date in the RCSB PDB.
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===Crystal Structure of A Viral Chemokine===
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Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.,Luz JG, Yu M, Su Y, Wu Z, Zhou Z, Sun R, Wilson IA J Mol Biol. 2005 Oct 7;352(5):1019-28. PMID:16140327<ref>PMID:16140327</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16140327}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zxt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16140327 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_16140327}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human gammaherpesvirus 8]]
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1ZXT is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXT OCA].
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[[Category: Large Structures]]
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[[Category: Luz JG]]
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==Reference==
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[[Category: Su Y]]
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<ref group="xtra">PMID:16140327</ref><references group="xtra"/>
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[[Category: Sun R]]
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[[Category: Human herpesvirus 8]]
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[[Category: Wilson IA]]
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[[Category: Luz, J G.]]
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[[Category: Wu Z]]
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[[Category: Su, Y.]]
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[[Category: Yu M]]
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[[Category: Sun, R.]]
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[[Category: Zhou Z]]
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[[Category: Wilson, I A.]]
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[[Category: Wu, Z.]]
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[[Category: Yu, M.]]
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[[Category: Zhou, Z.]]
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[[Category: Chemokine fold]]
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[[Category: Greek key motif]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:03:51 2010''
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Current revision

Crystal Structure of A Viral Chemokine

PDB ID 1zxt

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