3m3w
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3m3w is ON HOLD Authors: Meng Geng, Bai XiaoYun Description: Crystal strcuture of mouse PACSIN3 BAR domain mutant ''Page seeded by [http://oca.wei...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse PACSIN3 BAR domain mutant== | |
| - | + | <StructureSection load='3m3w' size='340' side='right'caption='[[3m3w]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3m3w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M3W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3w OCA], [https://pdbe.org/3m3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m3w RCSB], [https://www.ebi.ac.uk/pdbsum/3m3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3w ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PACN3_MOUSE PACN3_MOUSE] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Bai XY]] | ||
| + | [[Category: Meng G]] | ||
Current revision
Crystal structure of mouse PACSIN3 BAR domain mutant
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