3jth

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{{Seed}}
 
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[[Image:3jth.jpg|left|200px]]
 
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==Crystal structure of a transcriptional regulator HlyU from Vibrio vulnificus CMCP6==
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The line below this paragraph, containing "STRUCTURE_3jth", creates the "Structure Box" on the page.
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<StructureSection load='3jth' size='340' side='right' caption='[[3jth]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibvu Vibvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JTH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VV1_0512 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216895 VIBVU])</td></tr>
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{{STRUCTURE_3jth| PDB=3jth | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jth OCA], [http://pdbe.org/3jth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jth RCSB], [http://www.ebi.ac.uk/pdbsum/3jth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jth ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jth_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jth ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HlyU is a transcription factor of the ArsR/SmtB family and activates the expression of the pathogenic Vibrio vulnificus RTX toxin. In contrast to the other metal-responding ArsR/SmtB proteins, HlyU does not sense metal ions. To provide its structural information, we elucidated the crystal structure of HlyU from V. vulnificus CMCP6 (HlyU_Vv). The monomeric HlyU_Vv architecture of five alpha-helices and two beta-strands, some of which constitute a typical DNA-binding winged helix-turn-helix (wHTH) motif, is very similar to that of other transcription regulators. Nonetheless, the homo-dimeric HlyU_Vv structure shows several different, three-dimensional features in the spatial position and the detailed dimeric interaction, which were not observed in the modeling study based on the same protein family and sequence similarity.
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===Crystal structure of a transcriptional regulator HlyU from Vibrio vulnificus CMCP6===
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Crystal structure of the transcriptional activator HlyU from Vibrio vulnificus CMCP6.,Nishi K, Lee HJ, Park SY, Bae SJ, Lee SE, Adams PD, Rhee JH, Kim JS FEBS Lett. 2010 Mar 19;584(6):1097-102. Epub 2010 Feb 21. PMID:20178784<ref>PMID:20178784</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3jth" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20178784}}, adds the Publication Abstract to the page
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*[[Transcriptional activator|Transcriptional activator]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20178784 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20178784}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Vibvu]]
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3JTH is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Vibrio_vulnificus Vibrio vulnificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTH OCA].
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[[Category: Kim, J S]]
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[[Category: Lee, H J]]
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==Reference==
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[[Category: Nishi, K]]
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<ref group="xtra">PMID:20178784</ref><references group="xtra"/>
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[[Category: Park, S Y]]
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[[Category: Vibrio vulnificus]]
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[[Category: Kim, J S.]]
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[[Category: Lee, H J.]]
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[[Category: Nishi, K.]]
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[[Category: Park, S Y.]]
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[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Hlyu]]
[[Category: Hlyu]]
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[[Category: Transcription factor]]
[[Category: Transcription factor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:24:56 2010''
 

Current revision

Crystal structure of a transcriptional regulator HlyU from Vibrio vulnificus CMCP6

3jth, resolution 2.00Å

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