2x8a

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[[Image:2x8a.jpg|left|200px]]
 
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==Human Nuclear Valosin containing protein Like (NVL), C-terminal AAA- ATPase domain==
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The line below this paragraph, containing "STRUCTURE_2x8a", creates the "Structure Box" on the page.
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<StructureSection load='2x8a' size='340' side='right'caption='[[2x8a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2x8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2x8a| PDB=2x8a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8a OCA], [https://pdbe.org/2x8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8a RCSB], [https://www.ebi.ac.uk/pdbsum/2x8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8a ProSAT]</span></td></tr>
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</table>
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===HUMAN NUCLEAR VALOSIN CONTAINING PROTEIN LIKE (NVL), C-TERMINAL AAA-ATPASE DOMAIN===
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== Function ==
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[https://www.uniprot.org/uniprot/NVL_HUMAN NVL_HUMAN] Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).<ref>PMID:15469983</ref> <ref>PMID:16782053</ref> <ref>PMID:22226966</ref> <ref>PMID:26166824</ref> <ref>PMID:26456651</ref> <ref>PMID:28416111</ref> <ref>PMID:29107693</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2X8A is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8A OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8a ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Berglund, H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Berglund H]]
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[[Category: Collins, R.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Collins R]]
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[[Category: Flodin, S.]]
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[[Category: Edwards AM]]
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[[Category: Flores, A.]]
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[[Category: Flodin S]]
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[[Category: Graslund, S.]]
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[[Category: Flores A]]
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[[Category: Hammarstrom, M.]]
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[[Category: Graslund S]]
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[[Category: Johansson, I.]]
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[[Category: Hammarstrom M]]
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[[Category: Kallas, A.]]
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[[Category: Johansson I]]
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[[Category: Karlberg, T.]]
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[[Category: Kallas A]]
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[[Category: Kotenyova, T.]]
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[[Category: Karlberg T]]
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[[Category: Kraulis, P.]]
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[[Category: Kotenyova T]]
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[[Category: Moche, M.]]
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[[Category: Kraulis P]]
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[[Category: Nordlund, P.]]
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[[Category: Moche M]]
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[[Category: Nyman, T.]]
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[[Category: Nordlund P]]
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[[Category: Persson, C.]]
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[[Category: Nyman T]]
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[[Category: Schuetz, P.]]
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[[Category: Persson C]]
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[[Category: Schuler, H.]]
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[[Category: Schuetz P]]
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[[Category: Sehic, A.]]
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[[Category: Schuler H]]
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[[Category: Siponen, M I.]]
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[[Category: Sehic A]]
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[[Category: Svensson, L.]]
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[[Category: Siponen MI]]
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[[Category: Thorsell, A G.]]
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[[Category: Svensson L]]
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[[Category: Tresaugues, L.]]
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[[Category: Thorsell AG]]
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[[Category: Vandenberg, S.]]
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[[Category: Tresaugues L]]
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[[Category: Wahlberg, E.]]
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[[Category: VanDenBerg S]]
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[[Category: Weigelt, J.]]
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[[Category: Wahlberg E]]
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[[Category: Welin, M.]]
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[[Category: Weigelt J]]
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[[Category: Wisniewska, M.]]
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[[Category: Welin M]]
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[[Category: Nuclear protein]]
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[[Category: Wisniewska M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:38:05 2010''
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Current revision

Human Nuclear Valosin containing protein Like (NVL), C-terminal AAA- ATPase domain

PDB ID 2x8a

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