3lwk

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{{Seed}}
 
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[[Image:3lwk.jpg|left|200px]]
 
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==Crystal structure of human Beta-crystallin A4 (CRYBA4)==
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The line below this paragraph, containing "STRUCTURE_3lwk", creates the "Structure Box" on the page.
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<StructureSection load='3lwk' size='340' side='right'caption='[[3lwk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lwk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3lwk| PDB=3lwk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwk OCA], [https://pdbe.org/3lwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwk RCSB], [https://www.ebi.ac.uk/pdbsum/3lwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwk ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CRBA4_HUMAN CRBA4_HUMAN] Defects in CRYBA4 are the cause of cataract zonular type 2 (CZ2) [MIM:[https://omim.org/entry/610425 610425]; also known as lamellar cataract 2. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.<ref>PMID:16960806</ref> Defects in CRYBA4 are a cause of microphthalmia isolated with cataract type 4 (MCOPCT4) [MIM:[https://omim.org/entry/610426 610426]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.<ref>PMID:16960806</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CRBA4_HUMAN CRBA4_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lwk ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human Beta-crystallin A4 (CRYBA4)===
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==See Also==
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*[[Crystallin 3D structures|Crystallin 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Cataract, lamellar 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123631 123631]], Microphthalmia, isolated, with cataract 4 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123631 123631]]
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__TOC__
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</StructureSection>
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==About this Structure==
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3LWK is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWK OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Chaikuad, A.]]
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[[Category: Bountra C]]
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[[Category: Cocking, R.]]
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[[Category: Chaikuad A]]
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[[Category: Edwards, A M.]]
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[[Category: Cocking R]]
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[[Category: Krojer, T.]]
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[[Category: Edwards AM]]
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[[Category: Muniz, J R.C.]]
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[[Category: Krojer T]]
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[[Category: Oppermann, U.]]
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[[Category: Muniz JRC]]
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[[Category: Pike, A C.W.]]
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[[Category: Oppermann U]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Pike ACW]]
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[[Category: Shafqat, N.]]
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[[Category: Shafqat N]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Yue, W W.]]
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[[Category: Yue WW]]
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[[Category: Beta-crystallin]]
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[[Category: Cataract]]
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[[Category: Disease mutation]]
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[[Category: Eye lens protein]]
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[[Category: Microphthalmia]]
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[[Category: Oxidation]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:48:00 2010''
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Current revision

Crystal structure of human Beta-crystallin A4 (CRYBA4)

PDB ID 3lwk

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