This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1fv3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:16, 27 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1fv3.png|left|200px]]
 
-
<!--
+
==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B==
-
The line below this paragraph, containing "STRUCTURE_1fv3", creates the "Structure Box" on the page.
+
<StructureSection load='1fv3' size='340' side='right'caption='[[1fv3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1fv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FV3 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
-
{{STRUCTURE_1fv3| PDB=1fv3 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv3 OCA], [https://pdbe.org/1fv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv3 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fv3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fv3 ConSurf].
 +
<div style="clear:both"></div>
-
===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B===
+
==See Also==
-
 
+
*[[Tetanus toxin|Tetanus toxin]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11418600}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 11418600 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_11418600}}
+
-
 
+
-
==About this Structure==
+
-
1FV3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV3 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:11418600</ref><references group="xtra"/>
+
[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
-
[[Category: Ando, H.]]
+
[[Category: Large Structures]]
-
[[Category: Black, I.]]
+
[[Category: Ando H]]
-
[[Category: Emsley, P.]]
+
[[Category: Black I]]
-
[[Category: Fairweather, N F.]]
+
[[Category: Emsley P]]
-
[[Category: Fotinou, C.]]
+
[[Category: Fairweather NF]]
-
[[Category: Isaacs, N W.]]
+
[[Category: Fotinou C]]
-
[[Category: Ishida, H.]]
+
[[Category: Isaacs NW]]
-
[[Category: Kiso, M.]]
+
[[Category: Ishida H]]
-
[[Category: Sinha, K A.]]
+
[[Category: Kiso M]]
-
[[Category: Carbohydrate]]
+
[[Category: Sinha KA]]
-
[[Category: Ganglioside]]
+
-
[[Category: Multi-valent binding]]
+
-
[[Category: Receptor]]
+
-
[[Category: Toxin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 22 14:50:37 2010''
+

Current revision

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B

PDB ID 1fv3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fv3"
Personal tools