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3lny

From Proteopedia

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{{Seed}}
 
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[[Image:3lny.jpg|left|200px]]
 
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<!--
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==Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide==
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The line below this paragraph, containing "STRUCTURE_3lny", creates the "Structure Box" on the page.
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<StructureSection load='3lny' size='340' side='right'caption='[[3lny]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LNY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3lny| PDB=3lny | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lny OCA], [https://pdbe.org/3lny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lny RCSB], [https://www.ebi.ac.uk/pdbsum/3lny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lny ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN13_HUMAN PTN13_HUMAN] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.<ref>PMID:15611135</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ln/3lny_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lny ConSurf].
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<div style="clear:both"></div>
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===Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide===
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3LNY is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNY OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Large Structures]]
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[[Category: Chang, A.]]
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[[Category: Chang A]]
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[[Category: Jr., G N.Phillips.]]
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[[Category: Ke H]]
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[[Category: Ke, H.]]
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[[Category: Lee AL]]
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[[Category: Lee, A L.]]
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[[Category: Phillips Jr GN]]
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[[Category: Zhang, J.]]
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[[Category: Zhang J]]
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[[Category: Cell membrane]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Pdz2]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Signaling protein-signaling protein complex]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 09:06:11 2010''
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Current revision

Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide

PDB ID 3lny

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