3gh0

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{{Seed}}
 
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[[Image:3gh0.png|left|200px]]
 
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==Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability==
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The line below this paragraph, containing "STRUCTURE_3gh0", creates the "Structure Box" on the page.
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<StructureSection load='3gh0' size='340' side='right'caption='[[3gh0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GH0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3gh0| PDB=3gh0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gh0 OCA], [https://pdbe.org/3gh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gh0 RCSB], [https://www.ebi.ac.uk/pdbsum/3gh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gh0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/3gh0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gh0 ConSurf].
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<div style="clear:both"></div>
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===Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability===
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20151707}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20151707 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_20151707}}
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==About this Structure==
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3GH0 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GH0 OCA].
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==Reference==
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<ref group="xtra">PMID:20151707</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Thymidylate synthase]]
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[[Category: Large Structures]]
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[[Category: Bell, B J.]]
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[[Category: Bell BJ]]
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[[Category: Gibson, L M.]]
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[[Category: Gibson LM]]
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[[Category: Huang, X.]]
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[[Category: Huang X]]
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[[Category: Lebioda, L.]]
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[[Category: Lebioda L]]
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[[Category: Lovelace, L L.]]
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[[Category: Lovelace LL]]
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[[Category: Methyltransferase]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 13:09:02 2010''
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Current revision

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability

PDB ID 3gh0

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