3l3v

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{{Seed}}
 
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[[Image:3l3v.jpg|left|200px]]
 
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==Structure of HIV-1 integrase core domain in complex with sucrose==
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The line below this paragraph, containing "STRUCTURE_3l3v", creates the "Structure Box" on the page.
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<StructureSection load='3l3v' size='340' side='right'caption='[[3l3v]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l3v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L3V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3l3v| PDB=3l3v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3v OCA], [https://pdbe.org/3l3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l3v RCSB], [https://www.ebi.ac.uk/pdbsum/3l3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l3v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q72498_9HIV1 Q72498_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/3l3v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l3v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug design. IN has been shown to interact with a number of cellular and viral proteins during the integration process. Disruption of these important interactions could provide a mechanism for allosteric inhibition of IN. We present the highest resolution crystal structure of the IN core domain to date. We also present a crystal structure of the IN core domain in complex with sucrose which is bound at the dimer interface in a region that has previously been reported to bind integrase inhibitors.
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===Structure of HIV-1 integrase core domain in complex with sucrose===
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Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.,Wielens J, Headey SJ, Jeevarajah D, Rhodes DI, Deadman J, Chalmers DK, Scanlon MJ, Parker MW FEBS Lett. 2010 Apr 16;584(8):1455-62. Epub 2010 Mar 16. PMID:20227411<ref>PMID:20227411</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3l3v" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20227411}}, adds the Publication Abstract to the page
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*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20227411 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20227411}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3L3V is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3V OCA].
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==Reference==
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<ref group="xtra">PMID:20227411</ref><references group="xtra"/>
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Chalmers, D K.]]
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[[Category: Large Structures]]
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[[Category: Parker, M W.]]
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[[Category: Chalmers DK]]
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[[Category: Scanlon, M J.]]
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[[Category: Parker MW]]
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[[Category: Wielens, J.]]
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[[Category: Scanlon MJ]]
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[[Category: Aid]]
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[[Category: Wielens J]]
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[[Category: Dna binding]]
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[[Category: Dna integration]]
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[[Category: Endonuclease]]
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[[Category: Integrase]]
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[[Category: Polynucleotidyl transferase]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 13:36:17 2010''
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Current revision

Structure of HIV-1 integrase core domain in complex with sucrose

PDB ID 3l3v

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