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< User:Eran Hodis(Difference between revisions)
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| - | {{STRUCTURE_2ypi|PDB=2ypi|SCENE=}}
| + | <molshow refresh="50" size=300> |
| | | | |
| - | == Overview == | + | scene =User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Heme/1 |
| | + | caption=isolated Heme |
| | | | |
| - | '''Triose Phosphate Isomerase''' (TPI or TIM)is a ubiquitous enzyme with a molecular weight of 56 kD which catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate ([http://en.wikipedia.org/wiki/DHAP DHAP]) and D-glyceraldehyde-3-phosphate <scene name='Triose_Phosphate_Isomerase/Pga/1'>(GAP)</scene>, an essential process in the glycolytic pathway. More simply, the enzyme catalyzes the [http://en.wikipedia.org/wiki/Isomerization isomerization] of a ketose (DHAP) to an aldose [http://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate GAP] also referred to as PGAL. In regards to the two isomers, at equilibrium, roughly 96% of the triose phosphate is in the DHAP isomer form; however, the isomerization reaction proceeds due to the rapid removal of GAP from the subsequent reactions of [http://en.wikipedia.org/wiki/Glycolysis glycolysis]. TPI is an example of a [http://en.wikipedia.org/wiki/Catalytically_perfect_enzyme catalytically perfect enzyme], indicating that for almost every enzyme-substrate encounter, a product is formed and that this interaction is only limited by the substrate diffusion rate. Other catalytically perfect enzymes include [http://en.wikipedia.org/wiki/Carbonic_anhydrase carbonic anhydrase], [http://en.wikipedia.org/wiki/Acetylcholinesterase acetylcholinesterase], [http://en.wikipedia.org/wiki/Catalase catalase] and [http://en.wikipedia.org/wiki/Fumarase fumarase]. In addition to its relevance in glycolysis, TPI is also involved in metabolic biological processes such as gluconeogenesis, pentose phosphate shunt and fatty acid biosynthesis among others.
| + | scene = User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Sickle_hemoglobin_chain/1 |
| | + | caption = aggregate |
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| - | <scene name='User:Eran_Hodis/Sandbox3/Test/13'>TextToBeDisplayed</scene>
| + | scene = Journal:JBIC:3/Motif_good/5 |
| | + | caption = Here a long long explanation on what we could see |
| | + | from a closer look to the molecule |
| | + | if it were possible to make part of it transparent. |
| | + | |
| | + | </molshow> |
Current revision
<molshow refresh="50" size=300>
scene =User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Heme/1
caption=isolated Heme
scene = User:Jaime_Prilusky/How_do_we_get_the_oxygen_we_breathe/Sickle_hemoglobin_chain/1
caption = aggregate
scene = Journal:JBIC:3/Motif_good/5
caption = Here a long long explanation on what we could see
from a closer look to the molecule
if it were possible to make part of it transparent.
</molshow>
