2ocw

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{{Seed}}
 
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[[Image:2ocw.png|left|200px]]
 
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==Solution structure of human secretory component==
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The line below this paragraph, containing "STRUCTURE_2ocw", creates the "Structure Box" on the page.
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<StructureSection load='2ocw' size='340' side='right'caption='[[2ocw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ocw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OCW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ocw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocw OCA], [https://pdbe.org/2ocw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ocw RCSB], [https://www.ebi.ac.uk/pdbsum/2ocw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocw ProSAT]</span></td></tr>
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{{STRUCTURE_2ocw| PDB=2ocw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/2ocw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ocw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Secretory component (SC) in association with polymeric IgA (pIgA) forms secretory IgA, the major antibody active at mucosal surfaces. SC also exists in the free form, with innate-like neutralizing properties against pathogens. Free SC consists of five glycosylated variable (V)-type Ig domains (D1-D5), whose structure was determined by x-ray and neutron scattering, ultracentrifugation, and modeling. With a radius of gyration of 3.53-3.63 nm, a length of 12.5 nm, and a sedimentation coefficient of 4.0 S, SC possesses an unexpected compact structure. Constrained scattering modeling based on up to 13,000 trial models shows that SC adopts a J-shaped structure in which D4 and D5 are folded back against D2 and D3. The seven glycosylation sites are located on one side of SC, leaving known IgA-binding motifs free to interact with pIgA. This work represents the first analysis of the three-dimensional structure of full-length free SC and paves the way to a better understanding of the association between SC and its potential ligands, i.e. pIgA and pathogenic-associated motifs.
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===Solution structure of human secretory component===
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Solution structure of human secretory component and implications for biological function.,Bonner A, Perrier C, Corthesy B, Perkins SJ J Biol Chem. 2007 Jun 8;282(23):16969-80. Epub 2007 Apr 11. PMID:17428798<ref>PMID:17428798</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17428798}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ocw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17428798 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17428798}}
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: IgA nephropathy, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173880 173880]]
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==About this Structure==
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2OCW is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCW OCA].
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==Reference==
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<ref group="xtra">PMID:17428798</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bonner, A.]]
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[[Category: Large Structures]]
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[[Category: Corthesy, B.]]
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[[Category: Bonner A]]
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[[Category: Perkins, S J.]]
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[[Category: Corthesy B]]
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[[Category: Perrier, C.]]
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[[Category: Perkins SJ]]
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[[Category: Antibody]]
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[[Category: Perrier C]]
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[[Category: Immune system]]
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[[Category: Immunity]]
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[[Category: Immunoglobulin]]
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[[Category: Sc]]
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[[Category: Secretory]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:13:08 2010''
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Current revision

Solution structure of human secretory component

PDB ID 2ocw

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