1gzt

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[[Image:1gzt.gif|left|200px]]<br /><applet load="1gzt" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gzt, resolution 1.30&Aring;" />
 
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'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''<br />
 
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==Overview==
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==Pseudomonas aeruginosa lectin II (PA-IIL) together with fucose==
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Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and, PA-IIL) contribute to the virulence of this pathogenic bacterium, which is, a major cause of morbidity and mortality in cystic fibrosis patients. The, crystal structure of PA-IIL in complex with fucose reveals a tetrameric, structure. Each monomer displays a nine-stranded, antiparallel b-sandwich, arrangement and contains two close calcium cations that mediate the, binding of fucose in a recognition mode unique among carbohydrate-protein, interactions. Experimental binding studies, together with theoretical, docking of fucose-containing oligosaccharides, are consistent with the, assumption that antigens of the Lewis a (Le(a)) series may be the, preferred ligands of this lectin. Precise knowledge of the lectin-binding, site should allow a better design of new antibacterial-adhesion, prophylactics.
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<StructureSection load='1gzt' size='340' side='right'caption='[[1gzt]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1gzt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZT FirstGlance]. <br>
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1GZT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with FUC and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=FUA:Ca Binding Site For Chain D'>FUA</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzt OCA], [https://pdbe.org/1gzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzt RCSB], [https://www.ebi.ac.uk/pdbsum/1gzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzt ProSAT]</span></td></tr>
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Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12415289 12415289]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9HYN5_PSEAE Q9HYN5_PSEAE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gzt ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Gilboa-Garber N]]
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[[Category: Gilboa-Garber, N.]]
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[[Category: Imberty A]]
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[[Category: Imberty, A.]]
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[[Category: Mitchell E]]
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[[Category: Mitchell, E.]]
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[[Category: CA]]
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[[Category: FUC]]
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[[Category: fucose]]
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[[Category: lectin]]
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[[Category: sugar-binding protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 15:48:55 2007''
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Current revision

Pseudomonas aeruginosa lectin II (PA-IIL) together with fucose

PDB ID 1gzt

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