3k82

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{{Seed}}
 
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[[Image:3k82.jpg|left|200px]]
 
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==Crystal Structure of the third PDZ domain of PSD-95==
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The line below this paragraph, containing "STRUCTURE_3k82", creates the "Structure Box" on the page.
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<StructureSection load='3k82' size='340' side='right'caption='[[3k82]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3k82]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K82 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
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{{STRUCTURE_3k82| PDB=3k82 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k82 OCA], [https://pdbe.org/3k82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k82 RCSB], [https://www.ebi.ac.uk/pdbsum/3k82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k82 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/3k82_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k82 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the third PDZ domain of the neuronal post-synaptic density-95 protein (PSD95-PDZ3, residues 302-402) has been solved at 1.4 and 1.35A from two different crystal forms. These structures lack the cloning artefact present in the carboxyl terminal sequence of the former crystallographic structures and they belong to the space groups P4(3) and P1. The new PDZ structures are identical between the two crystal forms and among the four chains of the P1 crystal form. When we compare the new structures with the previous ones, some important conformational differences in the C-terminal alpha-helix and in the loop connecting beta2 and beta3 strands have been found. Additionally, the high resolution of the new structures has allowed us to indentify a succinimide residue at the position corresponding to Asp332 in the beta2-beta3 loop, which may contribute to the alternate conformation of this loop, and at the same time, to the interaction between residues from this loop and the C-terminal alpha-helix. Thus, these features would have implications in the recently proposed allosteric role of this third alpha-helix in the binding of the carboxyl terminal fragments to the PSD95-PDZ3.
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===Crystal Structure of the third PDZ domain of PSD-95===
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Novel conformational aspects of the third PDZ domain of the neuronal post-synaptic density-95 protein revealed from two 1.4A X-ray structures.,Camara-Artigas A, Murciano-Calles J, Gavira JA, Cobos ES, Martinez JC J Struct Biol. 2010 Jun;170(3):565-9. Epub 2010 Mar 19. PMID:20227506<ref>PMID:20227506</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3k82" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20227506 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20227506}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3K82 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K82 OCA].
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==Reference==
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<ref group="xtra">PMID:20227506</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Camara-Artigas, A.]]
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[[Category: Large Structures]]
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[[Category: Gavira, J A.]]
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[[Category: Camara-Artigas A]]
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[[Category: Alpha and beta protein]]
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[[Category: Gavira JA]]
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[[Category: Alternative splicing]]
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[[Category: Cell adhesion]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Palmitate]]
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[[Category: Phosphoprotein]]
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[[Category: Postsynaptic cell membrane]]
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[[Category: Sh3 domain]]
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[[Category: Synapse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:40:12 2010''
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Current revision

Crystal Structure of the third PDZ domain of PSD-95

PDB ID 3k82

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