1gop

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:1gop.png|left|200px]]
 
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==STRUCTURE OF THE C3B-BINDING SITE OF CR1 (CD35), THE IMMUNE ADHERENCE RECEPTOR==
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The line below this paragraph, containing "STRUCTURE_1gop", creates the "Structure Box" on the page.
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<StructureSection load='1gop' size='340' side='right'caption='[[1gop]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GOP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gop FirstGlance], [https://www.ebi.ac.uk/pdbsum/1gop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gop ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1gop| PDB=1gop | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Complement receptor type 1 (CR1 or CD35) is a multiple modular protein that mediates the immune adherence phenomenon, a fundamental event for destroying microbes and initiating an immunological response. It fulfills this role through binding C3b/C4b-opsonized foreign antigens. The structure of the principal C3b/C4b binding site (residues 901-1095) of CR1 is reported, revealing three complement control protein modules (modules 15-17) in an extended head-to-tail arrangement with flexibility at the 16-17 junction. Structure-guided mutagenesis identified a positively charged surface region on module 15 that is critical for C4b binding. This patch, together with basic side chains of module 16 exposed on the same face of CR1, is required for C3b binding. These studies reveal the initial structural details of one of the first receptor-ligand interactions to be identified in immunobiology.
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===STRUCTURE OF THE C3B-BINDING SITE OF CR1 (CD35), THE IMMUNE ADHERENCE RECEPTOR===
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Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor.,Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP, Barlow PN Cell. 2002 Mar 22;108(6):769-80. PMID:11955431<ref>PMID:11955431</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11955431}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gop" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11955431 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11955431}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GOP OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:11955431</ref><references group="xtra"/>
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[[Category: Atkinson, J P]]
[[Category: Atkinson, J P]]
[[Category: Barlow, P N]]
[[Category: Barlow, P N]]
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[[Category: Uhrin, D]]
[[Category: Uhrin, D]]
[[Category: Wang, X]]
[[Category: Wang, X]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 06:36:20 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

STRUCTURE OF THE C3B-BINDING SITE OF CR1 (CD35), THE IMMUNE ADHERENCE RECEPTOR

PDB ID 1gop

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