1t53

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{{Theoretical_model}}
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[[Image:1t53.png|left|200px]]
 
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==ATP REGULATED MODULE (ARM) DOMAIN OF ATRIAL NATRIURETIC FACTOR RECEPTOR GUANYLATE CYCLASE==
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The line below this paragraph, containing "STRUCTURE_1t53", creates the "Structure Box" on the page.
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<StructureSection load='1t53' size='340' side='right'caption='[[1t53]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T53 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t53 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1t53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t53 ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1t53| PDB=1t53 | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ATP is an obligatory agent for the atrial natriuretic factor (ANF) and the type C natriuretic peptide (CNP) signaling of their respective receptor guanylate cyclases, ANF-RGC and CNP-RGC. Through a common mechanism, it binds to a defined ARM domain of the cyclase, activates the cyclase and transduces the signal into generation of the second messenger cyclic GMP. In this presentation, the authors review the ATP-regulated transduction mechanism and refine the previously simulated three-dimensional ARM model (Duda T, Yadav P, Jankowska A, Venkataraman V, Sharma RK. Three dimensional atomic model and experimental validation for the ATP-regulated module (ARM) of the atrial natriuretic factor receptor guanylate cyclase. Mol Cell Biochem 2000;214:7-14; reviewed in: Sharma RK, Yadav P, Duda T. Allosteric regulatory step and configuration of the ATP-binding pocket in atrial natriuretic factor receptor guanylate cyclase transduction mechanism. Can J Physiol Pharmacol 2001;79: 682-91; Sharma RK. Evolution of the membrane guanylate cyclase transduction system. Mol Cell Biochem 2002;230:3-30). The model depicts the ATP-binding dependent configurational changes in the ARM and supports the concept that in the first step, ATP partially activates the cyclase and primes it for the subsequent transduction steps, resulting in full activation of the cyclase.
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===ATP REGULATED MODULE (ARM) DOMAIN OF ATRIAL NATRIURETIC FACTOR RECEPTOR GUANYLATE CYCLASE===
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ATP-regulated module (ARM) of the atrial natriuretic factor receptor guanylate cyclase.,Duda T, Venkataraman V, Ravichandran S, Sharma RK Peptides. 2005 Jun;26(6):969-84. Epub 2005 Apr 13. PMID:15911066<ref>PMID:15911066</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1t53" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15911066 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15911066}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T53 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:15911066</ref><references group="xtra"/>
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[[Category: Duda, T]]
[[Category: Duda, T]]
[[Category: Ravichandran, S]]
[[Category: Ravichandran, S]]
[[Category: Sharma, R K]]
[[Category: Sharma, R K]]
[[Category: Venkataraman, V]]
[[Category: Venkataraman, V]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 06:44:34 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

ATP REGULATED MODULE (ARM) DOMAIN OF ATRIAL NATRIURETIC FACTOR RECEPTOR GUANYLATE CYCLASE

PDB ID 1t53

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