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2hif

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:2hif.png|left|200px]]
 
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<!--
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==A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2==
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The line below this paragraph, containing "STRUCTURE_2hif", creates the "Structure Box" on the page.
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<StructureSection load='2hif' size='340' side='right'caption='[[2hif]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HIF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hif FirstGlance], [https://www.ebi.ac.uk/pdbsum/2hif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hif ProSAT]</span></td></tr>
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-->
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</table>
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{{STRUCTURE_2hif| PDB=2hif | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An atomic coordinate five alpha-helix three-dimensional model is presented for human interferon alpha-2 (HuIFN alpha 2). The HuIFN alpha 2 structure was constructed from murine interferon beta (MuIFN beta) by homology modeling using the STEREO and IMPACT programs. The HuIFN alpha 2 model is consistent with its known biochemical and biophysical properties including epitope mapping. Lysine residues predicted to be buried in the model were primarily unreactive with succinimidyl-7-amino-4-methylcoumarin-3-acetic acid (AMCA-NHS), a lysine modification agent, as shown by mass spectrometric analysis of tryptic digests. N-terminal sequence analysis of polypeptides generated by limited digestion of HuIFN alpha 2 with endoproteinase Lys-C demonstrated rapid cleavage at K31, which is consistent with the presence of this residue in a loop in the proposed HuIFN alpha 2 model. Based on this model structure potential receptor binding sites are identified.
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===A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2===
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A homology model of human interferon alpha-2.,Murgolo NJ, Windsor WT, Hruza A, Reichert P, Tsarbopoulos A, Baldwin S, Huang E, Pramanik B, Ealick S, Trotta PP Proteins. 1993 Sep;17(1):62-74. PMID:8234245<ref>PMID:8234245</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_8234245}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2hif" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 8234245 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8234245}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIF OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:8234245</ref><references group="xtra"/>
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[[Category: Ealick, S]]
[[Category: Ealick, S]]
[[Category: Hruza, A]]
[[Category: Hruza, A]]
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[[Category: Trotta, P P]]
[[Category: Trotta, P P]]
[[Category: Windsor, W T]]
[[Category: Windsor, W T]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 06:47:14 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2

PDB ID 2hif

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