1y9v

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:1y9v.png|left|200px]]
 
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==HOMOLOGY-BASED MODEL OF A HOMO-DIMER OF HUMAN CALPAIN 3 (P94) PENTA-EF HAND DOMAIN (DOMAIN IV)==
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The line below this paragraph, containing "STRUCTURE_1y9v", creates the "Structure Box" on the page.
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<StructureSection load='1y9v' size='340' side='right'caption='[[1y9v]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y9V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y9v FirstGlance], [https://www.ebi.ac.uk/pdbsum/1y9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y9v ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1y9v| PDB=1y9v | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Calpains 1 and 2 are heterodimeric proteases in which large (relative molecular mass M(r) 80000) and small (M(r) 28000) subunits are linked through their respective PEF (penta-EF-hand) domains. The skeletal muscle-specific calpain 3 is believed not to form a heterodimer with the small subunit but might homodimerize through its PEF domain. Size-exclusion chromatography and analytical ultracentrifugation of the recombinant PEF domain of calpain 3 show that it forms a stable homodimer that does not dissociate on dilution. Molecular modelling suggests that there would be no barriers to the dimerization of the whole enzyme through the PEF domains. This orientation would place the catalytic centres at opposite ends of the dimer.
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===HOMOLOGY-BASED MODEL OF A HOMO-DIMER OF HUMAN CALPAIN 3 (P94) PENTA-EF HAND DOMAIN (DOMAIN IV)===
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Homodimerization of calpain 3 penta-EF-hand domain.,Ravulapalli R, Diaz BG, Campbell RL, Davies PL Biochem J. 2005 Jun 1;388(Pt 2):585-91. PMID:15660530<ref>PMID:15660530</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15660530}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1y9v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15660530 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15660530}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y9V OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:15660530</ref><references group="xtra"/>
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[[Category: Campbell, R L]]
[[Category: Campbell, R L]]
[[Category: Davies, P L]]
[[Category: Davies, P L]]
[[Category: Garcia Diaz, B]]
[[Category: Garcia Diaz, B]]
[[Category: Ravulapalli, R]]
[[Category: Ravulapalli, R]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 06:53:05 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

HOMOLOGY-BASED MODEL OF A HOMO-DIMER OF HUMAN CALPAIN 3 (P94) PENTA-EF HAND DOMAIN (DOMAIN IV)

PDB ID 1y9v

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OCA

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