1iif

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:1iif.png|left|200px]]
 
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==STRUCTURAL BASE OF THE INTERACTION OF A MONOCLONAL ANTIBODY AGAINST P24 OF HIV-1 WITH ITS PEPTIDE EPITOPE==
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The line below this paragraph, containing "STRUCTURE_1iif", creates the "Structure Box" on the page.
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<StructureSection load='1iif' size='340' side='right'caption='[[1iif]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IIF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iif FirstGlance], [https://www.ebi.ac.uk/pdbsum/1iif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iif ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1iif| PDB=1iif | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The interaction of a murine monoclonal antibody (CB 4-1) against the core protein p24 of HIV-1 with its peptide antigen was studied in detail. The amino acid sequence of the variable regions of the heavy and light chain as derived from DNA sequencing was used to model the structure of the antigen binding region on the basis of reported Fab structures from the Brookhaven Protein Data Base. A linear peptide epitope responsible for the p24 binding to the antibody was determined by peptide scan. Subsequent N- and C-terminal truncation of the corresponding sequence region as well as amino acid substitutions were performed to recognize the epitope and the amino acid residues critical for antibody binding. These data were used to derive a structural model of the peptide-antibody interaction.
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===STRUCTURAL BASE OF THE INTERACTION OF A MONOCLONAL ANTIBODY AGAINST P24 OF HIV-1 WITH ITS PEPTIDE EPITOPE===
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Structural base of the interaction of a monoclonal antibody against p24 of HIV-1 with its peptide epitope.,Hohne WE, Kuttner G, Kiessig S, Hausdorf G, Grunow R, Winkler K, Wessner H, Giessmann E, Stigler R, Schneider-Mergener J, et al. Mol Immunol. 1993 Sep;30(13):1213-21. PMID:7692237<ref>PMID:7692237</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_7692237}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1iif" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 7692237 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7692237}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIF OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:7692237</ref><references group="xtra"/>
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[[Category: Hoehne, W E]]
[[Category: Hoehne, W E]]
[[Category: Stigler, R.-D]]
[[Category: Stigler, R.-D]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:07:21 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

STRUCTURAL BASE OF THE INTERACTION OF A MONOCLONAL ANTIBODY AGAINST P24 OF HIV-1 WITH ITS PEPTIDE EPITOPE

PDB ID 1iif

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