2g3u

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:2g3u.png|left|200px]]
 
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==HOMOLOGY MODEL OF AHCPK2 FROM GROUNDNUT==
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The line below this paragraph, containing "STRUCTURE_2g3u", creates the "Structure Box" on the page.
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<StructureSection load='2g3u' size='340' side='right'caption='[[2g3u]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3u FirstGlance], [https://www.ebi.ac.uk/pdbsum/2g3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3u ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2g3u| PDB=2g3u | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The signature of calcium-dependent protein kinases (CDPKs) is a C-terminal calmodulin-like domain (CaMLD) with four consensus calcium-binding sites. A junction domain (JD) joins the kinase with CaMLD and interacts with them through its autoinhibitory and CaMLD binding subdomains, respectively. We noted several CDPKs additionally have a bipartite nuclear localization signal (NLS) sequence as a subdomain in their JD, and this feature is obligatorily coupled with the absence of consensus calcium-binding sites in their respective CaMLDs. These predicted features are substantiated by undertaking investigations on a CDPK (gi:67479988) isolated from cultured groundnut (Arachis hypogea) cells. This kinase can bind 3.1 mol of Ca(2+) under saturating conditions with a considerably high K(d) of 392 mum as compared with its canonical counterparts. CD spectroscopic analysis, however, indicates the intramolecular structural changes accompanied with calcium binding to be similar to canonical CDPKs. Attesting to the presence of NLS in the JD, the endogenous kinase is localized in the nucleus of osmotically stressed Arachis cells, and in vitro binding assays indicate the NLS in the JD to interact with nuclear transport factors of the importin family. Homology modeling also indicates the feasibility of interaction of importins with the NLS present in the JD of such CDPKs in their activated form. The possible significance of obligatory coupling between the presence of NLS in the junction domain and atypical calcium binding properties of these CDPKs is discussed in the light of the known mechanisms of activation of these kinases.
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===HOMOLOGY MODEL OF AHCPK2 FROM GROUNDNUT===
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Domain analysis of a groundnut calcium-dependent protein kinase: nuclear localization sequence in the junction domain is coupled with nonconsensus calcium binding domains.,Raichaudhuri A, Bhattacharyya R, Chaudhuri S, Chakrabarti P, Dasgupta M J Biol Chem. 2006 Apr 14;281(15):10399-409. Epub 2006 Feb 7. PMID:16464867<ref>PMID:16464867</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2g3u" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16464867 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16464867}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3U OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:16464867</ref><references group="xtra"/>
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[[Category: Bhattacharyya, R]]
[[Category: Bhattacharyya, R]]
[[Category: Chakrabarti, P]]
[[Category: Chakrabarti, P]]
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[[Category: Dasgupta, M]]
[[Category: Dasgupta, M]]
[[Category: Raichaudhuri, A]]
[[Category: Raichaudhuri, A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:22:40 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

HOMOLOGY MODEL OF AHCPK2 FROM GROUNDNUT

PDB ID 2g3u

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