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1h8p

From Proteopedia

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[[Image:1h8p.jpg|left|200px]]<br /><applet load="1h8p" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1h8p, resolution 1.82&Aring;" />
 
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'''BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE'''<br />
 
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==Overview==
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==Bull seminal plasma PDC-109 fibronectin type II module==
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Bovine seminal plasma PDC-109 binds to sperm surface choline lipids and, promotes sperm capacitation by stimulating the efflux of cholesterol and, phospholipids. The structure of PDC-109 with bound phosphorylcholine was, solved using MAD data of a single platinum site. Its two globular (40 x 50, x 20 A(3)) Fn2 domains are linked and clustered by a short polypeptide., The choline binding sites lie at the same face of the molecule., Phosphorylcholine binds to the Fn2 domains through a cation-pi interaction, between the quaternary ammonium group and a core tryptophan, plus hydrogen, bonding between hydroxyls of exposed tyrosines and the phosphate group., The structure of the PDC-109-oPC complex provides a structural ground for, the sperm membrane-coating mechanism underlying PDC-109-induced, capacitation.
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<StructureSection load='1h8p' size='340' side='right'caption='[[1h8p]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1h8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H8P FirstGlance]. <br>
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1H8P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with PC as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Poc Binding Site For Residue A1111'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H8P OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8p OCA], [https://pdbe.org/1h8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h8p RCSB], [https://www.ebi.ac.uk/pdbsum/1h8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8p ProSAT]</span></td></tr>
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Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11937055 11937055]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SFP1_BOVIN SFP1_BOVIN] Could enhance the fertilizing capacity of bull spermatozoa upon interaction with heparin-like glycosaminoglycans present in the female genital tract. Exhibits both simulatory and inhibitory actions on the release of pituitary gonadotropins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h8p ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Calvete, J.J.]]
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[[Category: Calvete JJ]]
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[[Category: Fernandez-Tornero, C.]]
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[[Category: Fernandez-Tornero C]]
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[[Category: Romero, A.]]
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[[Category: Romero A]]
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[[Category: Wah, D.A.]]
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[[Category: Wah DA]]
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[[Category: PC]]
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[[Category: phosphorylcholine-binding protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:08:32 2007''
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Current revision

Bull seminal plasma PDC-109 fibronectin type II module

PDB ID 1h8p

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