1et2

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:1et2.png|left|200px]]
 
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==MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.==
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The line below this paragraph, containing "STRUCTURE_1et2", creates the "Structure Box" on the page.
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<StructureSection load='1et2' size='340' side='right'caption='[[1et2]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ET2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1et2 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1et2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1et2 ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1et2| PDB=1et2 | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroid hormone-related peptide (PTHrP), act on cells via a common PTH/PTHrP receptor. To define more precisely the ligand-receptor interactions, we have crystallized human PTH (hPTH)-(1-34) and determined the structure to 0.9-A resolution. hPTH-(1-34) crystallizes as a slightly bent, long helical dimer. Analysis reveals that the extended helical conformation of hPTH-(1-34) is the likely bioactive conformation. We have developed molecular models for the interaction of hPTH-(1-34) and hPTHrP-(1-34) with the PTH/PTHrP receptor. A receptor binding pocket for the N terminus of hPTH-(1-34) and a hydrophobic interface with the receptor for the C terminus of hPTH-(1-34) are proposed.
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===MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.===
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Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.,Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F J Biol Chem. 2000 Sep 1;275(35):27238-44. PMID:10837469<ref>PMID:10837469</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10837469}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1et2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10837469 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10837469}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ET2 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:10837469</ref><references group="xtra"/>
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[[Category: Briggs, S L]]
[[Category: Briggs, S L]]
[[Category: Chandrasekhar, S]]
[[Category: Chandrasekhar, S]]
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[[Category: Tashjian, A H]]
[[Category: Tashjian, A H]]
[[Category: Zhang, F]]
[[Category: Zhang, F]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:25:55 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

MOLECULAR MODEL OF THE CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 COMPLEXED WITH PTH/PTHRP RECEPTOR.

PDB ID 1et2

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