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1kje

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{{Theoretical_model}}
{{Theoretical_model}}
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[[Image:1kje.png|left|200px]]
 
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==THEORETICAL MODEL OF THE HUMAN CELL SURFACE RECEPTOR CD23, EXTRACELLULAR C-TYPE LECTIN DOMAIN, RESIDUES 178-285==
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The line below this paragraph, containing "STRUCTURE_1kje", creates the "Structure Box" on the page.
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<StructureSection load='1kje' size='340' side='right'caption='[[1kje]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kje FirstGlance], [https://www.ebi.ac.uk/pdbsum/1kje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kje ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1kje| PDB=1kje | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CD23, a type II membrane receptor protein, recognizes four different ligands via its extracellular C-type lectin domain: immunoglobulin E (IgE), CD21, and the beta 2-integrins CD11b and CD11c. CD23 specifically interacts in a calcium-dependent manner, "lectin-like" with carbohydrate moieties expressed on CD21 and CD11b/c, but also "lectin-unlike" with protein epitopes on IgE. As a first step in analyzing the multiple binding specificities associated with CD23 in more detail, we report a detailed molecular model of the lectin-like domain of human CD23 (hCD23). The model was built based on information provided by X-ray structures of mannose binding protein (MBP) and E-selectin, both of which are members of the calcium-dependent (C-type) lectin superfamily. Sequence-structure comparisons suggest that hCD23 is structurally more similar to MBP than to E-selectin. The hCD23 model is compared to an independently derived model. Although the CD23-carbohydrate and CD23-protein interactions are both calcium dependent, analysis of the model suggests the presence of distinct binding sites for these ligands.
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===THEORETICAL MODEL OF THE HUMAN CELL SURFACE RECEPTOR CD23, EXTRACELLULAR C-TYPE LECTIN DOMAIN, RESIDUES 178-285===
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Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.,Bajorath J, Aruffo A Protein Sci. 1996 Feb;5(2):240-7. PMID:8745401<ref>PMID:8745401</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_8745401}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1kje" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 8745401 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8745401}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJE OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:8745401</ref><references group="xtra"/>
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[[Category: Bajorath, J]]
[[Category: Bajorath, J]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:29:56 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

THEORETICAL MODEL OF THE HUMAN CELL SURFACE RECEPTOR CD23, EXTRACELLULAR C-TYPE LECTIN DOMAIN, RESIDUES 178-285

PDB ID 1kje

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