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1hc0

From Proteopedia

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[[Image:1hc0.gif|left|200px]]<br /><applet load="1hc0" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hc0, resolution 1.82&Aring;" />
 
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'''STRUCTURE OF LYSOZYME WITH PERIODATE'''<br />
 
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==Overview==
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==structure of lysozyme with periodate==
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The structure of tetragonal hen egg-white lysozyme soaked in a periodate, solution has been determined to a resolution of 1.8 A. Four high-occupancy, periodate positions have been identified on the basis of the anomalous, signal of the I atoms. The four periodates exhibit a regular rectangular, arrangement on the surface of the lysozyme molecule. No similar regular, arrangement was found either in lysozyme crystals soaked in other, heavy-atom anions or in other structures from the Protein Data Bank., Depending on their position on the surface of the protein, the periodate, ions deviate to a varying extent from ideal octahedral geometry.
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<StructureSection load='1hc0' size='340' side='right'caption='[[1hc0]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HC0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hc0 OCA], [https://pdbe.org/1hc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hc0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hc0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/1hc0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hc0 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1HC0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with IOD and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Known structural/functional Site: <scene name='pdbsite=AC1:Cl Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HC0 OCA].
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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Regular arrangement of periodates bound to lysozyme., Ondracek J, Weiss MS, Brynda J, Fiala J, Jursik F, Rezacova P, Jenner LB, Sedlacek J, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1181-9. Epub 2005, Aug 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16131750 16131750]
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Brynda J]]
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[[Category: Brynda, J.]]
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[[Category: Jursik F]]
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[[Category: Jursik, F.]]
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[[Category: Ondracek J]]
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[[Category: Ondracek, J.]]
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[[Category: Rezacova P]]
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[[Category: Rezacova, P.]]
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[[Category: Sedlacek J]]
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[[Category: Sedlacek, J.]]
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[[Category: CL]]
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[[Category: IOD]]
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[[Category: bacteriolytic enzyme]]
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[[Category: glycosidase]]
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[[Category: hydrolase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:15:42 2007''
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Current revision

structure of lysozyme with periodate

PDB ID 1hc0

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