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2f1u

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:2f1u.png|left|200px]]
 
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==A HOMOLOGY-BASED 3D MODEL OF THE HUMAN NEUROPEPTIDE Y RECEPTOR Y1==
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The line below this paragraph, containing "STRUCTURE_2f1u", creates the "Structure Box" on the page.
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<StructureSection load='2f1u' size='340' side='right'caption='[[2f1u]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F1U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f1u FirstGlance], [https://www.ebi.ac.uk/pdbsum/2f1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f1u ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2f1u| PDB=2f1u | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Interactions of the human NPY (neuropeptide Y) receptor Y1 with the two endogenous agonists NPY and peptide YY and two non-peptide antagonists were investigated using site-directed mutagenesis at 17 positions. The present study was triggered by contradictions among previously published reports and conclusions that seemed inconsistent with sequence comparisons across species and receptor subtypes. Our results show that Asp287, at the border between TM (transmembrane) region 6 and EL3 (extracellular loop 3) influences peptide binding, while two aspartic residues in EL2 do not, in agreement with some previous studies but in disagreement with others. A hydrophobic pocket of the Y1 receptor consisting of Tyr100 (TM2), Phe286 (TM6) and His298 (EL3) has been proposed to interact with the amidated C-terminus of NPY, a theory that is unsupported by sequence comparisons between Y1, Y2 and Y5. Nevertheless, our results confirm that these amino acid residues are critical for peptide binding, but probably interact with NPY differently than proposed previously. Studies with the Y1-selective antagonist SR120819A identified a new site of interaction at Asn116 in TM3. Position Phe173 in TM4 is also important for binding of this antagonist. In contrast with previous reports, we found that Phe173 is not crucial for the binding of BIBP3226, another selective Y1 receptor antagonist. Also, we found that position Thr212 (TM5) is important for binding of both antagonists. Our mutagenesis results and our three-dimensional model of the receptor based on the high-resolution structure of bovine rhodopsin suggest new interactions for agonist as well as antagonist binding to the Y1 receptor.
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===A HOMOLOGY-BASED 3D MODEL OF THE HUMAN NEUROPEPTIDE Y RECEPTOR Y1===
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Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study.,Sjodin P, Holmberg SK, Akerberg H, Berglund MM, Mohell N, Larhammar D Biochem J. 2006 Jan 1;393(Pt 1):161-9. PMID:16097949<ref>PMID:16097949</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_16097949}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2f1u" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16097949 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16097949}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1U OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:16097949</ref><references group="xtra"/>
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[[Category: Akerberg, H]]
[[Category: Akerberg, H]]
[[Category: Larhammar, D]]
[[Category: Larhammar, D]]
[[Category: Sjodin, P]]
[[Category: Sjodin, P]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:45:55 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

A HOMOLOGY-BASED 3D MODEL OF THE HUMAN NEUROPEPTIDE Y RECEPTOR Y1

PDB ID 2f1u

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