2ac6

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{{Theoretical_model}}
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[[Image:2ac6.png|left|200px]]
 
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==ANGIOTENSIN II TYPE 1A RECEPTOR MODEL==
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The line below this paragraph, containing "STRUCTURE_2ac6", creates the "Structure Box" on the page.
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<StructureSection load='2ac6' size='340' side='right'caption='[[2ac6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AC6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ac6 FirstGlance], [https://www.ebi.ac.uk/pdbsum/2ac6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ac6 ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2ac6| PDB=2ac6 | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present a three-dimensional model of the rat type 1 receptor (AT1) for the hormone angiotensin II (Ang II). Ang II and the AT1 receptor play a critical role in the cell-signaling process responsible for the actions of renin-angiotensin system in the regulation of blood pressure, water-electrolyte homeostasis and cell growth. Development of improved therapeutics would be significantly enhanced with the availability of a 3D-structure model for the AT1 receptor and of the binding site for agonists and antagonists. This model was constructed using a combination of computation and homology-modeling techniques starting with the experimentally determined three-dimensional structure of bovine rhodopsin (PDB#1F88) as a template. All 359 residues and two disulfide bonds in the rat AT1 receptor have been accounted for in this model. Ramachandran-map analysis and a 1 nanosecond molecular dynamics simulation of the solvated receptor with and without the bound ligand, Ang II, lend credence to the validity of the model. Docking calculations were performed with the agonist, Ang II and the antihypertensive antagonist, losartan. [Figure: see text].
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===ANGIOTENSIN II TYPE 1A RECEPTOR MODEL===
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Model of the whole rat AT1 receptor and the ligand-binding site.,Baleanu-Gogonea C, Karnik S J Mol Model. 2006 Feb;12(3):325-37. Epub 2006 Jan 11. PMID:16404618<ref>PMID:16404618</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16404618}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ac6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16404618 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16404618}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AC6 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:16404618</ref><references group="xtra"/>
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[[Category: Baleanu-Gogonea, C]]
[[Category: Baleanu-Gogonea, C]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:59:14 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

ANGIOTENSIN II TYPE 1A RECEPTOR MODEL

PDB ID 2ac6

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