1dn7
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{{Theoretical_model}} | {{Theoretical_model}} | ||
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- | [[Image:1dn7.png|left|200px]] | ||
- | + | ==THE CRYSTAL STRUCTURE OF D(*G-G-G-G-C-C-C-C). A MODEL FOR POLY(D*G)(DOT)POLY(D*C)== | |
- | + | <StructureSection load='1dn7' size='340' side='right'caption='[[1dn7]]' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DN7 FirstGlance]. <br> | |
- | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dn7 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1dn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dn7 ProSAT]</span></td></tr> | |
- | -- | + | </table> |
- | + | <div style="background-color:#fffaf0;"> | |
+ | == Publication Abstract from PubMed == | ||
+ | The structure of the DNA oligomer d(G-G-G-G-C-C-C-C) has been determined at a resolution of 2.5 A by single-crystal X-ray methods. There are two strands in the asymmetric unit, and these coil about each other to form a right-handed double-helix of the A-type with Watson-Crick hydrogen bonds between base-pairs. The helix has a shallow minor groove and a deep, water-filled major groove; almost all exposed functional groups on the DNA are hydrated, and 106 ordered solvent molecules have been found. The two d(G-G-G-G).d(C-C-C-C) segments in the octamer exhibit similar and uniform structures, but there is a slight discontinuity at the GpC step between them. A recurring feature of the structure is the overlap of adjacent guanine bases in each GpG step, with the five-membered ring of one guanine stacking on the six-membered ring of its neighbour. There is little or no overlap between adjacent cytosine rings. Conformational parameters for these GpG steps are compared with those from other single-crystal X-ray analyses. In general, GpG steps exhibit high slide, low roll and variable twist. Models for poly(dG).poly(dC) were generated by applying a simple rotation and translation to each of the unmodified d(G-G-G-G).d(C-C-C-C) units. Detailed features of these models are shown to be compatible with various assays of poly(dG).poly(dC) in solution, and are useful in understanding the polymorphic behaviour of this sequence under a variety of experimental conditions. | ||
- | + | The crystal structure of d(G-G-G-G-C-C-C-C). A model for poly(dG).poly(dC).,McCall M, Brown T, Kennard O J Mol Biol. 1985 Jun 5;183(3):385-96. PMID:4020865<ref>PMID:4020865</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | + | </div> | |
- | + | <div class="pdbe-citations 1dn7" style="background-color:#fffaf0;"></div> | |
- | + | == References == | |
- | + | <references/> | |
- | + | __TOC__ | |
- | + | </StructureSection> | |
- | == | + | [[Category: Theoretical Model]] |
- | + | [[Category: Large Structures]] | |
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- | == | + | |
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[[Category: Brown, T]] | [[Category: Brown, T]] | ||
[[Category: Kennard, O]] | [[Category: Kennard, O]] | ||
[[Category: Mccall, M J]] | [[Category: Mccall, M J]] | ||
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- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:00:58 2010'' |
Current revision
Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. |
THE CRYSTAL STRUCTURE OF D(*G-G-G-G-C-C-C-C). A MODEL FOR POLY(D*G)(DOT)POLY(D*C)
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