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1t30

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:1t30.png|left|200px]]
 
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==HOMOLOGY MODEL OF CDK1/CYCLIN B COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1t30", creates the "Structure Box" on the page.
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<StructureSection load='1t30' size='340' side='right'caption='[[1t30]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T30 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t30 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1t30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t30 ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1t30| PDB=1t30 | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular mechanics and hydropathic analysis with a protocol of constraints and local geometry searches. For the most part, our CKD1/cyclin B homology model is very similar to the high resolution CDK2/cyclin A crystal structure regarding secondary and tertiary features. However, minor discrepancies between the two kinase structures suggest the possibility that ligand design may be specifically tuned for either CDK1 or CDK2. Our examination of the CDK1/cyclin B model includes a comparison with the CDK2/cyclin A crystal structure in the PSTAIRE interface region, connecting portions to the ATP binding domain, as well as the ATP binding site itself.
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===HOMOLOGY MODEL OF CDK1/CYCLIN B COMPLEX===
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Homology model of the CDK1/cyclin B complex.,McGrath CF, Pattabiraman N, Kellogg GE, Lemcke T, Kunick C, Sausville EA, Zaharevitz DW, Gussio R J Biomol Struct Dyn. 2005 Apr;22(5):493-502. PMID:15702922<ref>PMID:15702922</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15702922}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1t30" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15702922 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15702922}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T30 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:15702922</ref><references group="xtra"/>
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[[Category: Gussio, R]]
[[Category: Gussio, R]]
[[Category: Kellogg, G E]]
[[Category: Kellogg, G E]]
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[[Category: Sausville, E A]]
[[Category: Sausville, E A]]
[[Category: Zaharevitz, D W]]
[[Category: Zaharevitz, D W]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:02:58 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

HOMOLOGY MODEL OF CDK1/CYCLIN B COMPLEX

PDB ID 1t30

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