2pai

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:2pai.png|left|200px]]
 
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==ELUCIDATING THE STRUCTURAL CHEMISTRY OF GLYCOSAMINOGLYCAN RECOGNITION BY PROTEIN C INHIBITOR==
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The line below this paragraph, containing "STRUCTURE_2pai", creates the "Structure Box" on the page.
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<StructureSection load='2pai' size='340' side='right'caption='[[2pai]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PAI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pai FirstGlance], [https://www.ebi.ac.uk/pdbsum/2pai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pai ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2pai| PDB=2pai | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glycosaminoglycans (GAGs) including heparin accelerate the inhibition of serine proteases by serine protease inhibitors (serpins), an essential process in regulating blood coagulation. to analyze the molecular basis for GAG recognition by the plasma serpin protein C inhibitor (PCI; also known as plasminogen activator inhibitor 3), we have constructed a complete, energy-minimized, three-dimensional model of PCI by using the structure of homologous alpha 1-antitrypsin as a template. Sequence analysis, hydrogen-bonding environment, and shape complementarity suggested that the N-terminal residues of PCI, which are not homologous to those of alpha 1-antitrypsin, form an amphipathic alpha-helix, here designated A+ since it precedes the alpha 1-antitrypsin A helix. Electrostatic calculations revealed a single, highly positive surface region arising from both the A+ and H helices, suggesting that this two-helix motif is required for GAG binding by PCI. The dominant role of electrostatic interactions in PCI-heparin binding was confirmed by the strong ionic strength dependence of heparin stimulation. The involvement of the A+ helix in heparin binding was verified by demonstrating that an anti-PCI antibody that specifically binds the A+ peptide blocks heparin binding.
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===ELUCIDATING THE STRUCTURAL CHEMISTRY OF GLYCOSAMINOGLYCAN RECOGNITION BY PROTEIN C INHIBITOR===
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Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.,Kuhn LA, Griffin JH, Fisher CL, Greengard JS, Bouma BN, Espana F, Tainer JA Proc Natl Acad Sci U S A. 1990 Nov;87(21):8506-10. PMID:2172989<ref>PMID:2172989</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_2172989}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2pai" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 2172989 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_2172989}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PAI OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:2172989</ref><references group="xtra"/>
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[[Category: Fisher, C L]]
[[Category: Fisher, C L]]
[[Category: Greengard, J S]]
[[Category: Greengard, J S]]
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[[Category: Kuhn, L A]]
[[Category: Kuhn, L A]]
[[Category: Tainer, J A]]
[[Category: Tainer, J A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:15:48 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

ELUCIDATING THE STRUCTURAL CHEMISTRY OF GLYCOSAMINOGLYCAN RECOGNITION BY PROTEIN C INHIBITOR

PDB ID 2pai

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