1p9t

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:1p9t.png|left|200px]]
 
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==CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS==
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The line below this paragraph, containing "STRUCTURE_1p9t", creates the "Structure Box" on the page.
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<StructureSection load='1p9t' size='340' side='right'caption='[[1p9t]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9t FirstGlance], [https://www.ebi.ac.uk/pdbsum/1p9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9t ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_1p9t| PDB=1p9t | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (Mpro, also called 3CLpro), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal structures for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro. The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV Mpro-mediated cleavage of a TGEV Mpro substrate. Molecular modeling suggests that available rhinovirus 3Cpro inhibitors may be modified to make them useful for treating SARS.
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===CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS===
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Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.,Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R Science. 2003 Jun 13;300(5626):1763-7. Epub 2003 May 13. PMID:12746549<ref>PMID:12746549</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12746549}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1p9t" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12746549 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12746549}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9T OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:12746549</ref><references group="xtra"/>
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[[Category: Anand, K]]
[[Category: Anand, K]]
[[Category: Hilgenfeld, R]]
[[Category: Hilgenfeld, R]]
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[[Category: Wadhwani, P]]
[[Category: Wadhwani, P]]
[[Category: Ziebuhr, J]]
[[Category: Ziebuhr, J]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:17:26 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS

PDB ID 1p9t

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