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5zna

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:5zna.png|left|200px]]
 
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==EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA==
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The line below this paragraph, containing "STRUCTURE_5zna", creates the "Structure Box" on the page.
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<StructureSection load='5zna' size='340' side='right'caption='[[5zna]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZNA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zna FirstGlance], [http://www.ebi.ac.uk/pdbsum/5zna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zna ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_5zna| PDB=5zna | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of Z-DNA, currently accepted as a model for all left-handed DNAs, fails to provide convincing explanations for at least four well established properties of left-handed DNA polymers in solution. However, the major discrepancies between theory and experiment are resolved by the structure presently proposed for Z[WC]-DNA, a new left-handed, zig-zag double helix with Watson-Crick-type backbone directions. Structural features of Z[WC]-DNA include the presence of an additional H-bond between each guanine N2-amino group and an adjacent phosphate oxygen, the capacity to form four-stranded, base-matched complexes that should readily precipitate from solution, and backbone progressions that are the same as B-DNA (opposite to Z-DNA). However, since Z[WC]-DNA and Z-DNA have many parameters in common, they could be difficult to distinguish in a majority of existing experiments. In view of the close relationship of the new helix to B-DNA, which allows a relatively unhindered right-to-left transition in handedness, Z[WC]-DNA is theorized to be the left-handed structure preferentially generated in vivo by the torque available in naturally occurring DNA supercoils.
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===EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA===
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Evidence for a new Z-type left-handed DNA helix: properties of Z(WC)-DNA.,Ansevin AT, Wang AH Nucleic Acids Res. 1990 Oct 25;18(20):6119-26. PMID:2235494<ref>PMID:2235494</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5zna" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_2235494}}, adds the Publication Abstract to the page
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*[[Z-DNA model tour|Z-DNA model tour]]
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(as it appears on PubMed at http://www.pubmed.gov), where 2235494 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_2235494}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZNA OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:2235494</ref><references group="xtra"/>
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[[Category: Ansevin, A T]]
[[Category: Ansevin, A T]]
[[Category: Wang, A H]]
[[Category: Wang, A H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:28:40 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA

PDB ID 5zna

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