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163d

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:163d.png|left|200px]]
 
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==A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS==
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The line below this paragraph, containing "STRUCTURE_163d", creates the "Structure Box" on the page.
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<StructureSection load='163d' size='340' side='right'caption='[[163d]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=163D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=163d FirstGlance], [https://www.ebi.ac.uk/pdbsum/163d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=163d ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_163d| PDB=163d | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Coordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others.
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===A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS===
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A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers.,Leclerc F, Cedergren R, Ellington AD Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035<ref>PMID:7664035</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_7664035}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 163d" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 7664035 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7664035}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=163D OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:7664035</ref><references group="xtra"/>
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[[Category: Cedergren, R J]]
[[Category: Cedergren, R J]]
[[Category: Ellington, A D]]
[[Category: Ellington, A D]]
[[Category: Leclerc, F]]
[[Category: Leclerc, F]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:31:02 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS

PDB ID 163d

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OCA

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