1psl
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{{Theoretical_model}} | {{Theoretical_model}} | ||
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| - | [[Image:1psl.png|left|200px]] | ||
| - | < | + | ==COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN== |
| - | + | <StructureSection load='1psl' size='340' side='right'caption='[[1psl]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psl FirstGlance], [https://www.ebi.ac.uk/pdbsum/1psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psl ProSAT]</span></td></tr> | |
| - | -- | + | </table> |
| - | + | <div style="background-color:#fffaf0;"> | |
| + | == Publication Abstract from PubMed == | ||
| + | Structural and environmental constraints greatly simplify the folding problem for membrane proteins. Computational methods can be used in a global search to find a small number of chemically reasonable models within these constraints, such that a modest set of experimental data can distinguish among them. We show that, for phospholamban, the global search can be further simplified by reducing the problem to two-body, rather than many-body, interactions. This method of a constrained global search combined with experimental mutagenesis data yields a three-dimensional structure for this pentameric ion channel. The model is a left-handed symmetric homopentamer of alpha-helices with a well-defined channel, lined solely by hydrophobic residues. | ||
| - | + | Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban.,Adams PD, Arkin IT, Engelman DM, Brunger AT Nat Struct Biol. 1995 Feb;2(2):154-62. PMID:7749920<ref>PMID:7749920</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1psl" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | [[Category: Theoretical Model]] |
| - | + | [[Category: Large Structures]] | |
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| - | == | + | |
| - | < | + | |
[[Category: Adams, P D]] | [[Category: Adams, P D]] | ||
[[Category: Arkin, I T]] | [[Category: Arkin, I T]] | ||
[[Category: Brunger, A T]] | [[Category: Brunger, A T]] | ||
[[Category: Engelman, D M]] | [[Category: Engelman, D M]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:41:15 2010'' | ||
Current revision
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COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN
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