2fvb

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:2fvb.png|left|200px]]
 
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==MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN==
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The line below this paragraph, containing "STRUCTURE_2fvb", creates the "Structure Box" on the page.
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<StructureSection load='2fvb' size='340' side='right'caption='[[2fvb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvb FirstGlance], [https://www.ebi.ac.uk/pdbsum/2fvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvb ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2fvb| PDB=2fvb | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Models of the Fv portion (containing the variable regions of the heavy and light chains) of two monoclonal anti-alpha (1----6)dextran antibodies, W3129 and 19.1.2, were constructed from amino acid sequences and the known three-dimensional structures of the Fv portions of McPC603 and J539. The modeled combining site of W3129 has a protrusion on one side, formed by the long complementarity-determining region 1 of the light chain and the long complementarity-determining region 3 of the heavy chain, and has a cavity accommodating a glucose moiety. The model of the 19.1.2 site is basically flat with a shallow groove that can accommodate several internal glucose units. These results support the earlier conclusions, from ligand binding data, that W3129 has a cavity-type site, involving the terminal nonreducing glucose residue (endbinder), whereas 19.1.2 has a groove-type site.
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===MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN===
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Model-building study of the combining sites of two antibodies to alpha (1----6)dextran.,Padlan EA, Kabat EA Proc Natl Acad Sci U S A. 1988 Sep;85(18):6885-9. PMID:2457920<ref>PMID:2457920</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_2457920}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2fvb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 2457920 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_2457920}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVB OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:2457920</ref><references group="xtra"/>
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[[Category: Kabat, E A]]
[[Category: Kabat, E A]]
[[Category: Padlan, E A]]
[[Category: Padlan, E A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:41:59 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN

PDB ID 2fvb

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