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2bu0

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{{Theoretical_model}}
{{Theoretical_model}}
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{{Seed}}
 
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[[Image:2bu0.png|left|200px]]
 
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==MOLECULAR MODEL OF THE SYNAPTIC SNARE COMPLEX, CONSISTING OF THE SYNAPTIC VESICLE PROTEIN VAMP2 AND PRESYNAPTIC PLASMA MEMBRANE PROTEINS SNAP-25 AND SYNTAXIN 1A, EPR STUDY AND MODELING==
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The line below this paragraph, containing "STRUCTURE_2bu0", creates the "Structure Box" on the page.
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<StructureSection load='2bu0' size='340' side='right'caption='[[2bu0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BU0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bu0 FirstGlance], [https://www.ebi.ac.uk/pdbsum/2bu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bu0 ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2bu0| PDB=2bu0 | SCENE= }}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The heterotrimeric synaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consisting of the synaptic vesicle-associated membrane protein 2 (VAMP2) and presynaptic plasma membrane proteins SNAP-25 (synaptosome-associated protein of 25,000 Mr) and syntaxin 1A, is a critical component of the exocytotic machinery. We have used spin labeling electron paramagnetic resonance spectroscopy to investigate the structural organization of this complex, particularly the two predicted helical domains contributed by SNAP-25. Our results indicate that the N- and C-terminal domains of SNAP-25 are parallel to each other and to the C-terminal domain of syntaxin 1A. Based on these findings, we propose a parallel four-stranded coiled coil model for the structure of the synaptic SNARE complex.
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===MOLECULAR MODEL OF THE SYNAPTIC SNARE COMPLEX, CONSISTING OF THE SYNAPTIC VESICLE PROTEIN VAMP2 AND PRESYNAPTIC PLASMA MEMBRANE PROTEINS SNAP-25 AND SYNTAXIN 1A, EPR STUDY AND MODELING===
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The synaptic SNARE complex is a parallel four-stranded helical bundle.,Poirier MA, Xiao W, Macosko JC, Chan C, Shin YK, Bennett MK Nat Struct Biol. 1998 Sep;5(9):765-9. PMID:9731768<ref>PMID:9731768</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9731768}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bu0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9731768 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9731768}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Theoretical Model]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BU0 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:9731768</ref><references group="xtra"/>
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[[Category: Bennett, M K]]
[[Category: Bennett, M K]]
[[Category: Chan, C]]
[[Category: Chan, C]]
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[[Category: Shin, Y K]]
[[Category: Shin, Y K]]
[[Category: Xiao, W]]
[[Category: Xiao, W]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:05:20 2010''
 

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

MOLECULAR MODEL OF THE SYNAPTIC SNARE COMPLEX, CONSISTING OF THE SYNAPTIC VESICLE PROTEIN VAMP2 AND PRESYNAPTIC PLASMA MEMBRANE PROTEINS SNAP-25 AND SYNTAXIN 1A, EPR STUDY AND MODELING

PDB ID 2bu0

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