2r7q

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[[Image:2r7q.png|left|200px]]
 
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==Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (C-terminal hexahistidine-tagged)==
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The line below this paragraph, containing "STRUCTURE_2r7q", creates the "Structure Box" on the page.
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<StructureSection load='2r7q' size='340' side='right'caption='[[2r7q]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_rotavirus Simian rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R7Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7q OCA], [https://pdbe.org/2r7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r7q RCSB], [https://www.ebi.ac.uk/pdbsum/2r7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r7q ProSAT]</span></td></tr>
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{{STRUCTURE_2r7q| PDB=2r7q | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RDRP_ROTSP RDRP_ROTSP] RNA-directed RNA polymerase that is involved in both transcription and genome replication. Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core. Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell. VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins. One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2. The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation. To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates. VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication. Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription.<ref>PMID:9371626</ref> <ref>PMID:19000820</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/2r7q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r7q ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (C-terminal hexahistidine-tagged)===
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19000820 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_19000820}}
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==About this Structure==
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2R7Q is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_rotavirus Simian rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7Q OCA].
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==Reference==
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<ref group="xtra">PMID:19000820</ref><references group="xtra"/>
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[[Category: Simian rotavirus]]
[[Category: Simian rotavirus]]
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[[Category: Harrison, S C.]]
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[[Category: Harrison SC]]
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[[Category: Lu, X.]]
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[[Category: Lu X]]
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[[Category: Nibert, M L.]]
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[[Category: Nibert ML]]
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[[Category: Patton, J T.]]
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[[Category: Patton JT]]
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[[Category: Tao, Y J.]]
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[[Category: Tao YJ]]
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[[Category: Finger]]
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[[Category: Palm]]
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[[Category: Right hand configuration]]
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[[Category: Rna-dependent rna polymerase]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Single subunit polymerase fold]]
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[[Category: Thumb]]
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[[Category: Transferase]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:14:37 2010''
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Current revision

Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (C-terminal hexahistidine-tagged)

PDB ID 2r7q

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