3lw1

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{{Seed}}
 
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[[Image:3lw1.png|left|200px]]
 
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==Binary complex of 14-3-3 sigma and p53 pT387-peptide==
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The line below this paragraph, containing "STRUCTURE_3lw1", creates the "Structure Box" on the page.
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<StructureSection load='3lw1' size='340' side='right'caption='[[3lw1]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LW1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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{{STRUCTURE_3lw1| PDB=3lw1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lw1 OCA], [https://pdbe.org/3lw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lw1 RCSB], [https://www.ebi.ac.uk/pdbsum/3lw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lw1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lw1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The adaptor protein 14-3-3 binds to and stabilizes the tumor suppressor p53 and enhances its anti-tumour activity. In the regulatory C-terminal domain of p53 several 14-3-3 binding motifs have been identified. Here, we report the crystal structure of the extreme C-terminus (residues 385-393, p53pT387) of p53 in complex with 14-3-3sigma at a resolution of 1.28A. p53pT387 is accommodated by 14-3-3 in a yet unrecognized fashion implying a rationale for 14-3-3 binding to the active p53 tetramer. The structure exhibits a potential binding site for small molecules that could stabilize the p53/14-3-3 protein complex suggesting the possibility for therapeutic intervention.
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===Binary complex of 14-3-3 sigma and p53 pT387-peptide===
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Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer.,Schumacher B, Mondry J, Thiel P, Weyand M, Ottmann C FEBS Lett. 2010 Apr 16;584(8):1443-8. Epub 2010 Mar 3. PMID:20206173<ref>PMID:20206173</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3lw1" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20206173}}, adds the Publication Abstract to the page
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20206173 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20206173}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3LW1 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW1 OCA].
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==Reference==
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<ref group="xtra">PMID:20206173</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mondry, J.]]
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[[Category: Large Structures]]
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[[Category: Ottmann, C.]]
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[[Category: Mondry J]]
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[[Category: Schumacher, B.]]
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[[Category: Ottmann C]]
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[[Category: Thiel, P.]]
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[[Category: Schumacher B]]
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[[Category: Weyand, M.]]
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[[Category: Thiel P]]
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[[Category: Adapter protein]]
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[[Category: Weyand M]]
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[[Category: Cytoplasm]]
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[[Category: Nucleus]]
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[[Category: Peptide binding protein]]
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[[Category: Phosphoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 08:49:19 2010''
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Current revision

Binary complex of 14-3-3 sigma and p53 pT387-peptide

PDB ID 3lw1

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