2b2n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:15, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2b2n.png|left|200px]]
 
-
<!--
+
==Structure of transcription-repair coupling factor==
-
The line below this paragraph, containing "STRUCTURE_2b2n", creates the "Structure Box" on the page.
+
<StructureSection load='2b2n' size='340' side='right'caption='[[2b2n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2b2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2N FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2b2n| PDB=2b2n | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2n OCA], [https://pdbe.org/2b2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2n RCSB], [https://www.ebi.ac.uk/pdbsum/2b2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2n ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MFD_ECOLI MFD_ECOLI] Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction, such as bound proteins. In addition, can rescue arrested complexes by promoting forward translocation. Has ATPase activity, which is required for removal of stalled RNAP, but seems to lack helicase activity. May act through a translocase activity that rewinds upstream DNA, leading either to translocation or to release of RNAP when the enzyme active site can not continue elongation.<ref>PMID:8465200</ref> <ref>PMID:7876261</ref> <ref>PMID:7876262</ref> <ref>PMID:12086674</ref> <ref>PMID:19700770</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2n_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b2n ConSurf].
 +
<div style="clear:both"></div>
-
===Structure of transcription-repair coupling factor===
+
==See Also==
-
 
+
*[[Transcription-repair coupling factor 3D structures|Transcription-repair coupling factor 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16309703}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 16309703 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Escherichia coli K-12]]
-
{{ABSTRACT_PUBMED_16309703}}
+
[[Category: Large Structures]]
-
 
+
[[Category: Assenmacher N]]
-
==About this Structure==
+
[[Category: Hopfner K-P]]
-
2B2N is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2N OCA].
+
[[Category: Lammens A]]
-
 
+
[[Category: Wenig K]]
-
==Reference==
+
-
<ref group="xtra">PMID:16309703</ref><references group="xtra"/>
+
-
[[Category: Escherichia coli k12]]
+
-
[[Category: Assenmacher, N.]]
+
-
[[Category: Hopfner, K P.]]
+
-
[[Category: Lammens, A.]]
+
-
[[Category: Wenig, K.]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Rna polymerase]]
+
-
[[Category: Rnap]]
+
-
[[Category: Strand-specific repair]]
+
-
[[Category: Template strand]]
+
-
[[Category: Transcription]]
+
-
[[Category: Uvra/b/c repair system]]
+
-
[[Category: X-ray crystallography]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 22 12:12:57 2010''
+

Current revision

Structure of transcription-repair coupling factor

PDB ID 2b2n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b2n"
Personal tools